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Research Project: Impact of Maternal Influence and Early Dietary Factors on Child Growth, Development, and Metabolic Health

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Title: Role of bacterial infections in extracellular vesicles release and impact on immune response

Author
item SPENCER, NICOLE - Arkansas Children'S Nutrition Research Center (ACNC)
item YERUVA, V. LAXMI - Arkansas Children'S Nutrition Research Center (ACNC)

Submitted to: BioMedical Journal
Publication Type: Review Article
Publication Acceptance Date: 5/4/2020
Publication Date: 5/23/2020
Citation: Spencer, N., Yeruva, V. 2020. Role of bacterial infections in extracellular vesicles release and impact on immune response. BioMedical Journal. https://doi.org/10.1016/j.bj.2020.05.006.
DOI: https://doi.org/10.1016/j.bj.2020.05.006

Interpretive Summary:

Technical Abstract: Extracellular vesicle (EV) biology involves understanding the cellular and molecular mechanisms of cell communication. Studies conducted so far with various bacterial infection models demonstrate the release of various types of EVs that include exosomes and microvesicles. Depending upon the infection and cell type, EV cargo composition changes and ultimately might impact the host immune response and bacterial growth. The mechanisms behind the EVs release, cargo composition, and impact on the immune system have not been fully investigated. Future research needs to include in vivo models to understand the relevance of EVs in host immune function during bacterial infection, and to determine aspects that are shared or species-specific in the host. This would aid in the development of EVs as therapeutics or as markers of disease.