Skip to main content
ARS Home » Pacific West Area » Logan, Utah » Poisonous Plant Research » Research » Publications at this Location » Publication #374406
Research Project: Understanding and Mitigating the Adverse Effects of Poisonous Plants on Livestock Production Systems

Location: Poisonous Plant Research

Title: Neurological syndrome in goats associated with Ipomoea trifida and Ipomoea carnea containing calystegines

Author
item SALINAS, LUIS - Antonio De Valdivieso Univav International University
item BALSEIRO, ANA - Agriculture Research And Development Service (SERIDA)
item JIRON, WILLIAM - National Autonomous University Of Nicaragua Unan At Leon
item PERALTA, ALAN - National Autonomous University Of Nicaragua Unan At Leon
item MUNOZ, DAVID - National Autonomous University Of Nicaragua Unan At Leon
item FAJARDO, JORGE - National Autonomous University Of Nicaragua Unan At Leon
item GAYO, ELENA - University Of Leon
item MARTINEZ, ILEANA - Upaep La Universidad Transformadora
item RIET-CORREA, FRANKLIN - National Agricultural Research Institute(INIA)
item Gardner, Dale
item MARIN, JUAN - University Of Leon

Submitted to: Toxicon
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/7/2018
Publication Date: 1/7/2019
Citation: Salinas, L.M., Balseiro, A., Jiron, W., Peralta, A., Munoz, D., Fajardo, J., Gayo, E., Martinez, I.Z., Riet-Correa, F., Gardner, D.R., Marin, J.F. 2019. Neurological syndrome in goats associated with Ipomoea trifida and Ipomoea carnea containing calystegines. Toxicon. 157:8-11. https://doi.org/10.1016/j.toxicon.2018.11.291.
DOI: https://doi.org/10.1016/j.toxicon.2018.11.291

Interpretive Summary: A disease characterized by ataxia, tremors and nystagmus had been observed in goats in Nicaragua. The main histologic lesions were loss and neuronal vacuolation of Purkinje cells and Wallerian-like degeneration mainly in the cerebellum, suggesting a glycoprotein storage disease. Ipomoea carnea and Ipomoea trifida found in the paddocks were negative for swainsonine, but contained calystegines at 0.02% and 0.06% suggesting that the disease was caused by these substances, which are competitive inhibitors of ß-glucosidase and a-galactosidase activities.

Technical Abstract: A disease characterized by ataxia, tremors and nystagmus had been observed in goats in Nicaragua. The main histologic lesions were loss and neuronal vacuolation of Purkinje cells and Wallerian-like degeneration mainly in the cerebellum, suggesting a glycoprotein storage disease. Ipomoea carnea and Ipomoea trifida found in the paddocks were negative for swainsonine, but contained calystegines at 0.02% and 0.06% suggesting that the disease was caused by these substances, which are competitive inhibitors of ß-glucosidase and a-galactosidase activities.