Author
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FIELDING ROGER A - TUFTS-HNRCA |
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Submitted to: Book Chapter
Publication Type: Book / Chapter Publication Acceptance Date: 1/1/1995 Publication Date: N/A Citation: N/A Interpretive Summary: Not required. Technical Abstract: The results of the studies discussed in the present review serve to document a coordinated series of metabolic changes which follow an acute bout of eccentric exercise and their relationship to alterations in non-specific host defense mechanisms. The similarity of this coordinated response to the stereotypical "acute phase response" to infection has led to the hypothesis that an acute phase response is induced by exercise. The acute phase response may be involved in the metabolic adaptations to exercise and the remodeling processes which skeletal muscles undergo in response to exercise training. This review has attempted to discuss the experimental evidence from human studies examining the changes in acute phase products and muscle protein turnover in association with primarily muscle damaging type activities. in addition, a discussion of the major proteolytic systems active in skeletal muscle has been presented to stim- ulate thinking about future studies aimed at addressing the controllers of muscle proteolysis in response to a host of exercise interventions. A further direction for future research should also focus on the effects of chronic exercise (including eccentrically biased activity) on long term changes in muscle protein turnover and the role of the circulating immune system and host defense responses in the adaptations to physical training. |
