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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #375512
Research Project: Nutrition, Epidemiology, and Healthy Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Proteomic and metabolomic correlates of healthy dietary patterns: the Framingham Heart Study

Author
item WALKER, MAURA - Boston University
item SONG, REBECCA - Boston University
item XU, XIANG - Boston University
item GERSZTEN, ROBERT - Beth Israel Deaconess Medical Center
item NGO, DEBBY - Beth Israel Deaconess Medical Center
item CLISH, CLARY - Broad Institute Of Mit/harvard
item CORLIN, LAURA - Tufts University
item MA, JIANTAO - Tufts University
item XANTHANKIS, VANESSA - Boston University
item JACQUES, PAUL - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item VASAN, RAMACHANDRAN - Framingham Heart Study

Submitted to: Nutrients
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/16/2020
Publication Date: 5/19/2020
Citation: Walker, M.E., Song, R.J., Xu, X., Gerszten, R.E., Ngo, D., Clish, C.B., Corlin, L., Ma, J., Xanthankis, V., Jacques, P.F., Vasan, R.S. 2020. Proteomic and metabolomic correlates of healthy dietary patterns: the Framingham Heart Study. Nutrients. 12(5):1476. https://doi.org/10.3390/nu12051476.
DOI: https://doi.org/10.3390/nu12051476

Interpretive Summary: Sub-optimal diet is a leading cause of death in the United States and contributes to nearly one-half of all heart disease and stroke related deaths. While higher quality diets appear to be a key factor in the prevention and mitigation of chronic disease, the means by which healthy diets affect disease risk remain largely unknown. The identification of markers of cellular metabolism (proteins and other metabolites) in blood that are related to dietary patterns holds promise to elucidate biological pathways underlying the diet-related risk of chronic disease. Our findings that over 300 proteins and other metabolites were associated with three measures of healthy diets, the Alternative Healthy Eating Index, the Dietary Approaches to Stop Hypertension (DASH) diet score, and a Mediterranean-style diet score, in a sample of community-dwelling middle-aged adults may offer novel insights into the key biological processes underlying diet-related chronic disease.

Technical Abstract: Background: The identification of molecular markers associated with dietary patterns may help characterize intermediate phenotypes that provide insights into the molecular mechanisms mediating diet-related disease. Data on proteomic and metabolomic signatures of healthy dietary patterns are limited. Objective: To examine the cross-sectional association of serum proteomic and metabolomic markers with three dietary patterns: the Alternative Healthy Eating Index (AHEI), the Dietary Approaches to Stop Hypertension (DASH) diet, and a Mediterranean-style (MDS) diet. Design: We examined participants from the Framingham Offspring Study (mean age, 55 years, 52% women) who had complete proteomic (n = 1,713) and metabolomic (n = 2,284) data, using food frequency questionnaires to derive dietary pattern indices. Proteins and metabolites were quantified using the SomaScan platform and liquid chromatography/tandem mass spectrometry, respectively. We used multivariable-adjusted linear regression models to relate each dietary pattern index (independent variables) to each proteomic and metabolomic marker (dependent variables). Results: Of the 1,373 proteins, 103 were associated with at least one dietary pattern (48 with AHEI, 83 with DASH, and 8 with MDS; all false discovery rate [FDR]