Nutrition and gastrointestinal microbiota, microbial derived secondary bile acids, and cardiovascular disease

Authors: RODRIGUEZ-MORATO, JOSE - Hospital Del Mar Medical Research Institute; MATTHAN, NIRUPA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Current Atherosclerosis Reports
Publication Type: Review Article
Publication Acceptance Date: 7/1/2020
Publication Date: 7/17/2020
Citation: Rodriguez-Morato, J., Matthan, N. 2020. Nutrition and gastrointestinal microbiota, microbial derived secondary bile acids, and cardiovascular disease. Current Atherosclerosis Reports. https://doi.org/10.1007/s11883-020-00863-7.
DOI: https://doi.org/10.1007/s11883-020-00863-7

Interpretive Summary:

Technical Abstract: Purpose of Review: The goal of this review is to further our understanding of the connection between gut microbiota and cardiovascular disease, with specific emphasis on bile acids, and the influence of diet in modulating this relationship. Recent Findings: Bile acids exert a much broader range of biological functions than initially recognized, including regulation of cardiovascular function through direct and indirect mechanisms. There is a bi-directional relationship between gut microbiota modulation of bile acid signaling properties, and their effects on gut microbiota composition. Evidence, primarily from rodent models and limited human trials, suggest that dietary modulation of the gut microbiome significantly impacts bile acid metabolism and subsequently host physiological response. Summary: Available evidence suggests that the link between diet, gut microbiota and CVD risk, is potentially mediated via bile acid effects on diverse metabolic pathways. However, further studies are needed to confirm/expand and translate these findings in a clinical setting.