Strategies to prevent or remediate cancer- and treatment-related aging

Authors: GUIDA, JENNIFER - National Institutes Of Health (NIH); AGURS-COLLINS, TANYA - National Institutes Of Health (NIH); AHLES, TIMA - Memorial Sloan Kettering; CAMPISI, JUDITH - Buck Institute For Age Research; DALE, WILLIAM - City Of Hope Medical Center; DEMARK-WAHNEFRIE, WENDY - University Of Alabama; DIETRICH, JORG - Massachusetts General Hospital; FULDNER, REBECCA - National Institutes Of Health (NIH); GALLICCHIO, LISA - National Institutes Of Health (NIH); GREEN, PAIGE - National Institutes Of Health (NIH); HURRIA, ARTI - City Of Hope Medical Center; JANELSINS, MICHELLE - University Of Rochester; JHAPPAN, CHAMELLI - National Institutes Of Health (NIH); KIRKLAND, JAMES - Mayo Clinic; KOHANSKI, RONALD - National Institutes Of Health (NIH); LONGO, VALTER - University Of Southern California; MEYDANI, SIMIN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University; MOHILE, SUPRIYA - University Of Rochester; NIEDERNHOFER, LAURA - University Of Minnesota; NELSON, CHRISTIAN - Memorial Sloan Kettering; PERNA, FRANK - National Institutes Of Health (NIH); SCHADLER, KERI - Md Anderson Cancer Center; SCOTT, JESSICA - Memorial Sloan Kettering; SCHRACK, JENNIFER - Johns Hopkins University; RUSSELL, TRACY - University Of Vermont; VAN DEURSEN, JAN - Mayo Clinic; NESS, KIRSTEN - St Jude Children’s Research Hospital

Submitted to: Journal of the National Cancer Institute
Publication Type: Review Article
Publication Acceptance Date: 4/16/2020
Publication Date: 4/29/2020
Citation: Guida, J.L., Agurs-Collins, T., Ahles, T.A., Campisi, J., Dale, W., Demark-Wahnefrie, W., Dietrich, J., Fuldner, R., Gallicchio, L., Green, P.A., Hurria, A., Janelsins, M.C., Jhappan, C., Kirkland, J.L., Kohanski, R., Longo, V., Meydani, S.N., Mohile, S., Niedernhofer, L.J., Nelson, C., Perna, F., Schadler, K.L., Scott, J.M., Schrack, J.A., Russell, T.P., Van Deursen, J., Ness, K.K. 2020. Strategies to prevent or remediate cancer- and treatment-related aging. Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/djaa060.
DOI: https://doi.org/10.1093/jnci/djaa060

Interpretive Summary:

Technical Abstract: Up to 85% of adult cancer survivors and 99% of adult survivors of childhood cancer live with an accumulation of chronic conditions, frailty, and/or cognitive impairments resulting from cancer and its treatment. Thus, survivors often show an accelerated development of multiple geriatric syndromes and need therapeutic interventions. To advance progress in this area, the National Cancer Institute convened the second of two think tanks under the auspices of the Cancer and Accelerated Aging: Advancing Research for Healthy Survivors initiative. Experts assembled to share evidence of promising strategies to prevent, slow, or reverse the aging consequences of cancer and its treatment. The meeting identified research and resource needs, including geroscience-guided clinical trials; comprehensive assessments of functional, cognitive, and psychosocial vulnerabilities to assess and predict age-related outcomes; preclinical and clinical research to determine the optimal dosing for behavioral (e.g., diet, exercise) and pharmacologic (e.g., senolytic) therapies; healthcare delivery research to evaluate the efficacy of integrated cancer care delivery models; optimization of intervention implementation, delivery, and uptake; and patient/provider education on cancer and treatment-related late and long-term adverse effects. Addressing these needs will expand knowledge of aging-related consequences of cancer and cancer treatment and inform strategies to promote healthy aging of cancer survivors.