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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #376213
Research Project: Personalized Nutrition and Healthy Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Lifestyle interventions for the prevention and treatment of hypertension

Author
item VALENZUELA, PEDRO - University Of Alcala
item CARRERA-BASTOS, PEDRO - Center For Primary Health Care Research
item GALVEZ, BEATRIZ - Hospital Universitario 12 De Octubre
item RUIZ-HURTADO, GEMA - Hospital Universitario 12 De Octubre
item ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item RUILOPE, LUIS - Hospital Universitario 12 De Octubre
item LUCIA, ALEJANDRO - Hospital Universitario 12 De Octubre

Submitted to: Nature Reviews Cardiology
Publication Type: Review Article
Publication Acceptance Date: 6/12/2020
Publication Date: 10/9/2020
Citation: Valenzuela, P.L., Carrera-Bastos, P., Galvez, B.G., Ruiz-Hurtado, G., Ordovas, J.M., Ruilope, L.M., Lucia, A. 2020. Lifestyle interventions for the prevention and treatment of hypertension. Nature Reviews Cardiology. 18(4):251-275. https://doi.org/10.1038/s41569-020-00437-9.
DOI: https://doi.org/10.1038/s41569-020-00437-9

Interpretive Summary:

Technical Abstract: Hypertension affects approximately one-third of the world's adult population and continues to be a major cause of mortality despite considerable advances in pharmacological treatments. Growing evidence supports the use of lifestyle interventions for the prevention and adjuvant treatment of hypertension. This Review provides a summary of the epidemiological research supporting the preventive and anti-hypertensive effects of major lifestyle interventions (notably, regular physical exercise, body weight management, and following a healthy dietary pattern, as well as other less classical recommendations such as promotion of adequate sleep patterns coupled with circadian entrainment, and stress management). We also discuss the physiological mechanisms underlying lifestyle benefits on hypertension, which include not only prevention of traditional risk factors (e.g., obesity, insulin resistance) or improvements in vascular health through an enhanced redox and inflammatory status, but also reduced sympathetic overactivation and non-traditional mechanisms (e.g., increased secretion of myokines).