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ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #377073
Title: Childhood gastroparesis is a unique entity in need of further investigation

Author
item FEBO-RODRIGUEZ, L - Baylor College Of Medicine
item CHUMPITAZI, BRUNO - Texas Children'S Hospital
item SHULMAN, ROBERT - Children'S Nutrition Research Center (CNRC)

Submitted to: Neurogastroenterology & Motility
Publication Type: Review Article
Publication Acceptance Date: 7/30/2019
Publication Date: 8/13/2019
Citation: Febo-Rodriguez, L., Chumpitazi, B.P., Shulman, R.J. 2019. Childhood gastroparesis is a unique entity in need of further investigation. Neurogastroenterology & Motility. 32:e13699. https://doi.org/10.1111/nmo.13699.
DOI: https://doi.org/10.1111/nmo.13699

Interpretive Summary:

Technical Abstract: Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children and lack of GP-specific pediatric reported outcome measures. The aim of this article was to review the available literature on pediatric GP and identify similarities and differences with studies in adults. We performed a comprehensive search in MEDLINE and Google Scholar from inception to April 2019 for articles published in English using the following combination of keywords: gastroparesis, pediatric gastroparesis, outcomes, metoclopramide, erythromycin, domperidone, cisapride, and gastric neurostimulator. The limited available pediatric data, often retrospective, suggest marked differences between adult and pediatric GP in several aspects including etiology, concomitant co-morbidities (eg, psychiatric disorders), clinical symptom presentation, diagnostic evaluation, response to therapies, and clinical outcome. Further research in pediatric GP is needed and holds the promise to further elucidate the mechanisms of this disorder in children and lead to pediatric-focused therapies.