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Title: Associations of abdominal pain and psychosocial distress measures with health-related quality-of-life in pediatric healthy controls and irritable bowel syndrome

Author
item HOLLIER, JOHN - Baylor College Of Medicine
item CZYZEWSKI, DANITA - Texas Children'S Hospital
item SELF, MARIELLA - Texas Children'S Hospital
item LIU, YAN - Baylor College Of Medicine
item WEIDLER, ERICA - Children'S Nutrition Research Center (CNRC)
item VAN TILBURG, MIRANDA - University Of North Carolina
item VARNI, JAMES - Texas A&M University
item SHULMAN, ROBERT - Children'S Nutrition Research Center (CNRC)

Submitted to: Journal of Clinical Gastroenterology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/11/2020
Publication Date: 6/16/2020
Citation: Hollier, J.M., Czyzewski, D.I., Self, M.M., Liu, Y., Weidler, E.M., Van Tilburg, M.A., Varni, J.W., Shulman, R.J. 2020. Associations of abdominal pain and psychosocial distress measures with health-related quality-of-life in pediatric healthy controls and irritable bowel syndrome. Journal of Clinical Gastroenterology. https://doi.org/10.1097/MCG.0000000000001373.
DOI: https://doi.org/10.1097/MCG.0000000000001373

Interpretive Summary: Children with irritable bowel syndrome have a lower health-related quality of life. This study found that somatization (symptoms that cannot be fully explained by the presence of a medical condition) was an important factor affecting quality of life. Knowledge from our study supports the utilization of psychosocial interventions (counseling, educational programs, nutritional guidance) that may help to improve the overall well-being for children that have irritable bowel.

Technical Abstract: Children with irritable bowel syndrome (IBS) have lower health-related quality-of-life (HRQOL) than healthy controls (HC). Abdominal pain and psychosocial distress are negatively associated with HRQOL, although their relative effect is unclear. The aim of this study was to compare the relative associations of abdominal pain and psychosocial distress with HRQOL in HC and IBS. The aim of this study was to compare the relative associations of abdominal pain and psychosocial distress with HRQOL in HC and IBS. Baseline abdominal pain, psychosocial distress, and HRQOL measures were obtained from HC and IBS pediatric clinical trial participants. Regression assessed which measures were most strongly associated with Physical and Psychosocial HRQOL separately by group. Interaction analyses examined group differences in the associations of abdominal pain and psychosocial distress with HRQOL.Eight-five HC and 213 children with IBS participated. Somatization was most strongly associated with Physical HRQOL in HC, and functional disability was most strongly related in IBS.