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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Publications at this Location » Publication #381444
Research Project: Intervention Strategies to Control Endemic and New and Emerging Viral Diseases of Swine

Location: Virus and Prion Research

Title: Angiotensin-converting enzyme 2 (ACE2) receptor on the surface of mammalian cells and evolution of ACE2-related immunogenetic diversity to restrict SARS-CoV2 infections

Author
item MILLER, LAURA

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 1/29/2021
Publication Date: 2/28/2021
Citation: Miller, L.C. 2021. Angiotensin-converting enzyme 2 (ACE2) receptor on the surface of mammalian cells and evolution of ACE2-related immunogenetic diversity to restrict SARS-CoV2 infections [Abstract]. USDA-Western Regional Research Center (WRRC)- Pacific West Area (PWA).Virtual.

Interpretive Summary:

Technical Abstract: “For cross-species animal tropism, the potential infectivity of SARS-CoV-2 in both wild and domestic animals, and potential for zoonotic transmission is a big public health concern. That concern involves two aspects: (1) screening to identify the animal species that serve as a virus reservoir originally passing SARS-CoV-2 to humans; and (2) the existing risk of infected people to pass the virus to animals, particularly the domestic species, thus potentially forming an amplifying zoonotic cycle. In this study, we evaluate cross-species ACE2 genetic (and especially epigenetic) diversity in regulation of ACE2 expression and functionality to determine the potential cell tropism and animal susceptibility to SARS-CoV-2.”