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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Infectious Bacterial Diseases Research » Research » Publications at this Location » Publication #382485
Research Project: Characterize the Immunopathogenesis and Develop Diagnostic and Mitigation Strategies to Control Tuberculosis in Cattle and Wildlife

Location: Infectious Bacterial Diseases Research

Title: Genome sequences of Mycobacterium tuberculosis Biovar bovis strains Ravenel and 10-7428

Author
item HADI, SYEDA - Michigan State University
item BRENNER, EVAN - Michigan State University
item RINOSH, M - Michigan State University
item Palmer, Mitchell
item THACKER, TYLER - Animal And Plant Health Inspection Service (APHIS)
item SREEVATSAN, SRINAND - Michigan State University

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/24/2021
Publication Date: 6/17/2021
Citation: Hadi, S.A., Brenner, E.P., Rinosh, M., Palmer, M.V., Thacker, T., Sreevatsan, S. 2021. Genome sequences of Mycobacterium tuberculosis Biovar bovis strains Ravenel and 10-7428. Genome Announcements. https://doi.org/10.1128/mra.00411-21.
DOI: https://doi.org/10.1128/mra.00411-21

Interpretive Summary: Understanding the differences between strains of the bacteria that cause bovine tuberculosis is helpful in determining the mechanisms by which disease develops and progresses. We sequenced the genetic material of 2 strains of Mycobacterium bovis, one from a Colorado dairy considered to be highly disease causing and the other a strain isolated in the early 1900s and maintained in a laboratory.

Technical Abstract: We report the draft genome of two Mycobacterium tuberculosis variant bovis strains. Strain Ravenel isolated in 1900’s and maintained in rabbits, is shown to be experimentally attenuated in recent cattle studies. Whereas the other strain 10-7428 is considered a highly pathogenic strain in cattle.