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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #384537
Research Project: Energy Met.: Novel Approaches to Facilitating Successful Energy Regulation in Aging--Obesity & Met.: Role of Adipocyte Metabolism in the Development of Obesity and Associated Metabolic Complications

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: The good and bad of adipose tissue macrophage exosomes in obesity

Author
item GREENBERG, ANDREW - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item REEVES, ANDREW - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Cell Metabolism
Publication Type: Review Article
Publication Acceptance Date: 4/6/2021
Publication Date: 4/6/2021
Citation: Greenberg, A., Reeves, A. 2021. The good and bad of adipose tissue macrophage exosomes in obesity. Cell Metabolism. 33(4):700-702. https://doi.org/10.1016/j.cmet.2021.03.011.
DOI: https://doi.org/10.1016/j.cmet.2021.03.011

Interpretive Summary:

Technical Abstract: Adipose tissue macrophages regulate adipose tissue inflammation and systemic insulin-glucose homeostasis. In a recent study by Ying et. al. (2021), M2 polarized bone marrow-derived macrophages secreted exosomes containing miR-690 that, when administered to obese mice, improved glucose-insulin homeostasis. miR-690 reduced expression of Nadk which decreased inflammation and improved insulin signaling.