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Research Project: Ecology of Vesicular Stomatitis Virus (VSV) in North America

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Title: Immunobiology of Crimean-Congo hemorrhagic fever

Author
item RODRIGUEZ, SERGIO - Centers For Disease Control And Prevention (CDC) - United States
item HAWMAN, DAVID - Rocky Mountain Laboratories National Institute Of Allergy And Infectious Diseases (NIAID)
item SORVILLO, TERESA - Centers For Disease Control And Prevention (CDC) - United States
item O’NEAL, TROY - Centers For Disease Control And Prevention (CDC) - United States
item BIRD, BRIAN - Centers For Disease Control And Prevention (CDC) - United States
item Rodriguez, Luis
item FELDMANN, HEINZ - Rocky Mountain Laboratories National Institute Of Allergy And Infectious Diseases (NIAID)
item BERGERON, ÉRIC - Centers For Disease Control And Prevention (CDC) - United States
item NICHOL, STUART - Centers For Disease Control And Prevention (CDC) - United States
item MONTGOMERY, JOEL - Centers For Disease Control And Prevention (CDC) - United States
item SPIROPOULOU, CHRISTINA - Centers For Disease Control And Prevention (CDC) - United States
item SPENGLER, JESSICA - Centers For Disease Control And Prevention (CDC) - United States

Submitted to: Antiviral Research
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/6/2022
Publication Date: 1/11/2022
Citation: Rodriguez, S.E., Hawman, D.W., Sorvillo, T.E., O’Neal, T.J., Bird, B.H., Rodriguez, L.L., Feldmann, H., Bergeron, É., Nichol, S.T., Montgomery, J.M., Spiropoulou, C.F., Spengler, J.R. 2022. Immunobiology of Crimean-Congo hemorrhagic fever. Antiviral Research. https://doi.org/10.1016/j.antiviral.2022.105244.
DOI: https://doi.org/10.1016/j.antiviral.2022.105244

Interpretive Summary: Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-transmitted pathogen that infects ruminants (e.g. sheep, catle) and when transmitted to humans causes a spectrum of disease, ranging from mild clinical signs to severe or fatal disease. In this review we discuss the role of immune responses in determining the severity of disease. We summarize what is known about the role of the immune response in disease based on natural and experimental infection, and from evaluation of immune-based therapies and vaccines; and present recommendations for future research.

Technical Abstract: Infection with Crimean-Congo hemorrhagic fever virus (CCHFV) can result in a spectrum of disease, ranging from mild clinical signs to severe or fatal disease. Studies of CCHFV Immunobiology have investigated the association of innate and adaptive immune responses with disease severity, attempting to elucidate factors associated with differential outcomes. Here we highlight unanswered questions and discuss current efforts to answer these questions. We then review, in detail, research to date on the immunobiology of CCHF, including immune targets of infection, and immune responses to infection, both innate and adaptive. We summarize what is known about the role of the immune response in disease based on natural and experimental infection, and from evaluation of immune-based therapies and vaccines; and present recommendations for future research.