Location: Chemistry Research
Title: Kaempferol as a precursor for ubiquinone (coenzyme Q) biosynthesis: An atypical node between specialized metabolism and primary metabolismAuthor
BERGER, ANTOINE - University Of Florida | |
LATIMER, SCOTT - University Of Florida | |
STUTTS, LAUREN - University Of Florida | |
SOUBEYRAND, ERIC - University Of Florida | |
Block, Anna | |
BASSET, GILLES - University Of Florida |
Submitted to: Current Opinion in Plant Biology
Publication Type: Review Article Publication Acceptance Date: 12/1/2021 Publication Date: 1/10/2022 Citation: Berger, A., Latimer, S., Stutts, L.R., Soubeyrand, E., Block, A.K., Basset, G.J. 2022. Kaempferol as a precursor for ubiquinone (coenzyme Q) biosynthesis: An atypical node between specialized metabolism and primary metabolism. Current Opinion in Plant Biology. 66, 102165. https://doi.org/10.1016/j.pbi.2021.102165. DOI: https://doi.org/10.1016/j.pbi.2021.102165 Interpretive Summary: Technical Abstract: About 25% of 4-hydroxybenzoate that serves as an aromatic ring precursor of the vital respiratory cofactor and liposoluble antioxidant ubiquinone (coenzyme Q), originates from the catabolism of the flavonol, kaempferol. Biochemical and genetic evidence indicates that the release of 4-hydroxybenzoate from kaempferol is catalyzed by heme-dependent peroxidases, and that 3-O-glycosylations of kaempferol act as a negative regulator of this process. New frontiers for investigations include examining if ubiquinone contributes to the ROS scavenging and signaling roles that have been historically assigned to flavonols, as well as taking advantage of the metabolic node between flavonols and ubiquinone to manipulate oxidative stress resistance in crops. |