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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #388988
Research Project: Energy Met.: Novel Approaches to Facilitating Successful Energy Regulation in Aging--Obesity & Met.: Role of Adipocyte Metabolism in the Development of Obesity and Associated Metabolic Complications

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Energy compensation and adiposiy in humans

Author
item CAREAU, VINCENT - UNIVERSITY OF OTTAWA
item HALSEY, LEWIS - UNIVERSITY OF ROEHAMPTON
item PONTZER, HERMAN - DUKE UNIVERSITY
item AINSLIE, PHILIP - JOHN MOORES UNIVERSITY
item ANDERSEN, LENE - UNIVERSITY OF OSLO
item ANDERSON, LIAM - JOHN MOORES UNIVERSITY
item ARAB, LENORE - UNIVERSITY OF CALIFORNIA
item BADDOU, ISSAAD - UNIVERSITE IBN TOFAIL
item BEDU-ADDO, KWEKU - KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
item BLAAK, ELLEN - MAASTRICHT UNIVERSITY
item BLANC, STEPHANE - UNIVERSITÉ DE STRASBOURG: ACCUEIL
item BONOMI, ALBERTO - PHILIPS RESEARCH EINDHOVEN
item BOUTEN, CARLIJN - EINDHOVEN UNIVERSITY OF TECHNOLOGY
item BUCHOWSKI, MACIEJ - VANDERBILT UNIVERSITY
item BUTTE, NANCY - CHILDREN'S NUTRITION RESEARCH CENTER (CNRC)
item CAMPS, STEFAN - MAASTRICHT UNIVERSITY
item CLOSE, GRAEME - JOHN MOORES UNIVERSITY
item COOPER, JAMIE - UNIVERSITY OF WISCONSIN
item DAS, SAI KRUPA - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY
item COOPER, RICHARD - LOYOLA UNIVERSITY
item DUGAS, LARA - LOYOLA UNIVERSITY
item EATON, SIMON - UNIVERSITY COLLEGE LONDON
item EKELUND, ULF - NORWEGIAN SCHOOL OF SPORT SCIENCES
item ENTRINGER, SONJA - UNIVERSITY OF CALIFORNIA
item FORRESTER, TERRENCE - UNIVERSITY OF THE WEST INDIES
item FUDGE, BARRY - UNIVERSITY OF GLASGOW
item GORIS, ANNELIES - MAASTRICHT UNIVERSITY
item GURVEN, MICHAEL - UNIVERSITY OF CALIFORNIA
item HAMBLY, CATHERINE - UNIVERSITY OF ABERDEEN
item EL HAMDOUCHI, ASMAA - UNIVERSITE IBN TOFAIL
item HOOS, MARIJE - MAASTRICHT UNIVERSITY
item HU, SUMEI - CHINESE ACADEMY OF SCIENCES
item JOONAS, NOORJEHAN - MINISTRY OF AGRO INDUSTRY AND FOOD SECURITY-MAURITIUS
item JOOSEN, ANNAMIEK - MAASTRICHT UNIVERSITY
item KATZMARZYK, PETER - PENNINGTON BIOMEDICAL RESEARCH CENTER
item KEMPEN, KITTY - MAASTRICHT UNIVERSITY
item KIMURA, MISAKA - NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION
item KRAUS, WILLIAM - DUKE UNIVERSITY
item KUSHNER, ROBERT - NORTHWESTERN UNIVERSITY
item LAMBERT, ESTELLE - UNIVERSITY OF CAPE TOWN
item LEONARD, WILLIAM - NORTHWESTERN UNIVERSITY
item LESSAN, NADER - IMPERIAL COLLEGE
item MARTIN, CORBY - PENNINGTON BIOMEDICAL RESEARCH CENTER
item MEDIN, ANINE - UNIVERSITY OF AGDER
item MEIJER, ERWIN - MAASTRICHT UNIVERSITY
item MOREHEN, JAMES - THE FA GROUP
item MORTON, JAMES - JOHN MOORES UNIVERSITY
item NEUHOUSER, MARIAN - UNIVERSITY OF WASHINGTON
item NICKLAS, THERESA - CHILDREN'S NUTRITION RESEARCH CENTER (CNRC)
item OJJAMBO, ROBERT - MOI UNIVERSITY
item PIETILAINEN, KIRSI - HELSINKI HOSPITAL
item PITSILADIS, YANNIS - THE UNIVERSITY OF BRIGHTON
item PLANGE-RHULE, JACOB - KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
item PLASQUE, GUY - MAASTRICHT UNIVERSITY
item PRENTICE, ROSS - UNIVERSITY OF WASHINGTON
item RABINOVICH, ROBERTO - UNIVERSITY OF EDINBURGH
item RACETTE, SUSAN - WASHINGTON UNIVERSITY
item RAICHLEN, DAVID - UNIVERSITY OF SOUTHERN CALIFORNIA
item RAVUSSIN, ERIC - PENNINGTON BIOMEDICAL RESEARCH CENTER
item REILLY, JOHN - UNIVERSITY OF STRATHCLYDE
item REYNOLDS, REBECCA - UNIVERSITY OF EDINBURGH
item ROBERTS, SUSAN - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY
item SCHUIT, ALBERTINE - TILBURG UNIVERSITY
item SJODIN, ANDERS - COPENHAGEN UNIVERSITY
item STOCE, EROC - STANFORD UNIVERSITY
item URLACHER, SAMUEL - BAYLOR UNIVERSITY
item VALENTI, GIULIO - MAASTRICHT UNIVERSITY
item VAN ETTEN, LUDO - MAASTRICHT UNIVERSITY
item VAN MIL, EDGAR - MAASTRICHT UNIVERSITY
item WELLS, JONATHAN - UCL GREAT ORMOND STREET INSTITUTE OF CHILD HEALTH
item WILSON, GEORGE - JOHN MOORES UNIVERSITY
item WOOD, BRIAN - UNIVERSITY OF CALIFORNIA
item YANOVSKI, JACK - NATIONAL INSTITUTES OF HEALTH (NIH)
item YOSHIDA, TSUKASA - UNIVERSITY OF TSUKUBA
item ZHANG, XUEYING - CHINESE ACADEMY OF SCIENCES
item MURPHY-ALFORD, ALEXIA - INTERNATIONAL ATOMIC ENERGY AGENCY (IAEA)
item LOECHL, CORNELIA - INTERNATIONAL ATOMIC ENERGY AGENCY (IAEA)
item LUKE, AMY - LOYOLA UNIVERSITY
item ROOD, JENNIFER - PENNINGTON BIOMEDICAL RESEARCH CENTER
item SAGAYAMA, HIRO - UNIVERSITY OF TSUKUBA
item SCHOELLER, DALE - UNIVERSITY OF WISCONSIN
item WONG, WILLIAM - CHILDREN'S NUTRITION RESEARCH CENTER (CNRC)
item YAMADA, YOSUKE - NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION
item SPEAKMAN, JOHN - UNIVERSITY OF ABERDEEN

Submitted to: Current Biology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/4/2021
Publication Date: 8/27/2021
Citation: Careau, V., Halsey, L.G., Pontzer, H., Ainslie, P.N., Andersen, L.F., Anderson, L.J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E.E., Blanc, S., Bonomi, A.G., Bouten, C.V., Buchowski, M.S., Butte, N.F., Camps, S.G., Close, G.L., Cooper, J., Das, S., Cooper, R., Dugas, L., Eaton, S.D., Ekelund, U., Entringer, S., Forrester, T., Fudge, B.W., Goris, A.H., Gurven, M., Hambly, C., El Hamdouchi, A., Hoos, M.B., Hu, S., Joonas, N., Joosen, A.M., Katzmarzyk, P., Kempen, K.P., Kimura, M., Kraus, W.E., Kushner, R., Lambert, E.V., Leonard, W.B., Lessan, N., Martin, C.K., Medin, A.C., Meijer, E.P., Morehen, J.C., Morton, J.P., Neuhouser, M., Nicklas, T., Ojjambo, R.M., Pietilainen, K.H., Pitsiladis, Y.P., Plange-Rhule, J., Plasque, G., Prentice, R., Rabinovich, R.A., Racette, S.B., Raichlen, D.A., Ravussin, E., Reilly, J.J., Reynolds, R., Roberts, S., Schuit, A.J., Sjodin, A.M., Stoce, E., Urlacher, S.S., Valenti, G., Van Etten, L.M., Van Mil, E.A., Wells, J.C., Wilson, G., Wood, B.M., Yanovski, J., Yoshida, T., Zhang, X., Murphy-Alford, A.J., Loechl, C., Luke, A.M., Rood, J., Sagayama, H., Schoeller, D.A., Wong, W.W., Yamada, Y., Speakman, J.R. 2021. Energy compensation and adiposiy in humans. Current Biology. https://doi.org/10.1016/j.cub.2021.08.016.
DOI: https://doi.org/10.1016/j.cub.2021.08.016

Interpretive Summary: This analysis of the largest collection of doubly labeled water data on total daily energy expenditure combined with measures of body composition, 1754 measurements in adults > 18 years, examined how energy expenditure is related to body fatness. The results show that energy requirements are more similar between people who have different levels of body fat because although metabolic rate is higher there is a reduction in energy expenditure for activity. These results help explain the relative stability of energy requirements across people with different body types, and have implications for the design of successful approaches to weight management.

Technical Abstract: Understanding the impacts of activity on energy balance is crucial. Increasing levels of activity may bring diminishing returns in energy expenditure because of compensatory responses in non-activity energy expenditures. This suggestion has profound implications for both the evolution of metabolism and human health. It implies that a long-term increase in activity does not directly translate into an increase in total energy expenditure (TEE) because other components of TEE may decrease in response - energy compensation. We used the largest dataset complied on adult TEE and basal energy expenditure (BEE) (N=1,754) of people living normal lives to find that energy compensation by a typical human averages 28% due to reduced BEE; this suggests that only 72% of the extra calories we burn from additional activity translates into extra calories burned that day. Moreover, the dress of energy compensation varied considerably between people of difference body composition. This association between compensation and adiposity could be due to among-individual differences in compensation; people who compensate more may b more likely to accumulate body fat. Alternatively, the process might occur within individuals; as we get fatter, our bodies might compensate more strongly or the calories burned during activity, making losing fat progressively more difficult. Determining the causality of the relationship between energy compensation and adiposity will be the key to improving public health strategies regarding obesity.