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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #389332
Research Project: Energy Met.: Novel Approaches to Facilitating Successful Energy Regulation in Aging--Obesity & Met.: Role of Adipocyte Metabolism in the Development of Obesity and Associated Metabolic Complications

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition

Author
item RIMBACH, REBECCA - Duke University
item YAMADA, YOSUKE - National Institutes Of Biomedical Innovation
item SAGAYAMA, HIROYUKI - University Of Tsukuba
item AINSLIE, PHILIP - Liverpool John Moores University
item ANDERSEN, LENE - University Of Oslo
item ANDERSON, LIAM - Liverpool John Moores University
item ARAB, LENORE - University Of California
item BADDOU, ISSAAD - Universite Ibn Tofail
item BEDU-ADDO, KWEKU - Kwame Nkrumah University Of Science And Technology
item BLAAK, ELLEN - Maastricht University
item BLANC, STEPHANE - University Of Wisconsin
item BONOMI, ALBERTO - Philips Research Eindhoven
item BOUTEN, CARLIJN - Eindhoven University Of Technology
item BOVET, PASCAL - Lausanne University Hospital
item BUCHOWSKI, MACIEJ - Vanderbilt University
item BUTTE, NANCY - Children'S Nutrition Research Center (CNRC)
item CAMPS, STEFAN - Maastricht University
item CLOSE, GRAEME - Liverpool John Moores University
item COOPER, JAMIE - University Of Wisconsin
item DAS, SAI KRUPA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item DUGAS, LARA - Loyola University
item EKELUND, ULF - Norwegian School Of Sport Sciences
item ENTRINGER, SONJA - University Of California
item FORRESTER, TERRENCE - University Of The West Indies
item FUDGE, BARRY - University Of Glasgow
item GORIS, ANNELIES - Maastricht University
item GURVEN, MICHAEL - University Of California
item HAMBLY, CATHERINE - University Of Aberdeen
item EL HAMDOUCHI, ASMAA - Universite Ibn Tofail
item HOOS, MARIJE - Maastricht University
item HU, SUMEI - Chinese Academy Of Sciences
item JOONAS, NOORJEHAN - Mauritius Ministry Of Health And Wellness
item JOOSEN, ANNEMIEK - Maastricht University
item KATZMARZYK, PETER - Pennington Biomedical Research Center
item KEMPEN, KITTY - Maastricht University
item KIMURA, MISAKA - Kyoto University
item KRAUS, WILLIAM - Duke University
item KUSHNER, ROBERT - Northwestern University
item LAMBERT, ESTELLE - University Of Cape Town
item LEONARD, WILLIAM - Northwestern University
item LESSAN, NADER - Imperial College
item MARTIN, CORBY - Pennington Biomedical Research Center
item MEDIN, ANINE - University Of Agder
item MEIJER, ERWIN - Maastricht University
item MOREHEN, JAMES - The Fa Group
item MORTON, JAMES - Liverpool John Moores University
item NEUHOUSER, MARIAN - Fred Hutchinson Cancer Research Center
item NICKLAS, THERESA - Baylor College Of Medicine
item OJIAMBO, ROBERT - Moi University
item PIETILAINEN, KIRSI - Helsinki University Hospital
item PITSILADIS, YANNIS - The University Of Brighton
item PLANGE-RHULE, JACOB - Kwame Nkrumah University Of Science And Technology
item PLASQUI, GUY - Maastricht University
item PRENTICE, ROSS - University Of Washington
item RABINOVICH, ROBERTO - University Of Edinburgh
item RACETTE, SUSAN - Washington University
item RAICHLEN, DAVID - University Of Southern California
item RAVUSSIN, ERIC - Pennington Biomedical Research Center
item REYNOLDS, REBECCA - University Of Edinburgh
item ROBERTS, SUSAN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item SCHUIT, ALBERTINE - Tilburg University
item SJODIN, ANDERS - Copenhagen University
item STICE, ERIC - Stanford University
item URLACHER, SAMUEL - Baylor University
item VALENTI, GIULIO - Maastricht University
item VAN ETTEN, LUDO - Maastricht University
item VAN MIL, EDGAR - Maastricht University
item WELLS, JONATHAN - Ucl Great Ormond Street Institute Of Child Health
item WILSON, GEORGE - Liverpool John Moores University
item WOOD, BRIAN - University Of Southern California
item YANOVSKI, JACK - National Institutes Of Health (NIH)
item YOSHIDA, TSUKASA - University Of Tsukuba
item ZHANG, XUEYING - Chinese Academy Of Sciences
item MURPHY-ALFORD, ALEXIA - International Atomic Energy Agency (IAEA)
item LOECHL, CORNELIA - International Atomic Energy Agency (IAEA)
item LUKE, AMY - Loyola University
item ROOD, JENNIFER - Pennington Biomedical Research Center
item SCHOELLER, DALE - University Of Wisconsin
item WESTERTERP, KLAAS - Maastricht University
item WONG, WILLIAM - Children'S Nutrition Research Center (CNRC)
item SPEAKMAN, JOHN - University Of Aberdeen
item PONTZER, HERMAN - Duke University

Submitted to: Nature Communications
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/4/2021
Publication Date: 1/10/2022
Citation: Rimbach, R., Yamada, Y., Sagayama, H., Ainslie, P.N., Andersen, L.F., Anderson, L.J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E.E., Blanc, S., Bonomi, A.G., Bouten, C.V., Bovet, P., Buchowski, M.S., Butte, N.F., Camps, S.G., Close, G.L., Cooper, J., Das, S., Dugas, L.L., Ekelund, U., Entringer, S., Forrester, T., Fudge, B.W., Goris, A.H., Gurven, M., Hambly, C., El Hamdouchi, A., Hoos, M.B., Hu, S., Joonas, N., Joosen, A.M., Katzmarzyk, P., Kempen, K.P., Kimura, M., Kraus, W.E., Kushner, R., Lambert, E.V., Leonard, W.R., Lessan, N., Martin, C.K., Medin, A.C., Meijer, E.P., Morehen, J.C., Morton, J.P., Neuhouser, M.L., Nicklas, T., Ojiambo, R.M., Pietilainen, K.H., Pitsiladis, Y.P., Plange-Rhule, J., Plasqui, G., Prentice, R., Rabinovich, R.A., Racette, S.B., Raichlen, D.A., Ravussin, E., Reynolds, R., Roberts, S., Schuit, A.J., Sjodin, A.M., Stice, E., Urlacher, S.S., Valenti, G., Van Etten, L.M., Van Mil, E.A., Wells, J.C., Wilson, G., Wood, B., Yanovski, J., Yoshida, T., Zhang, X., Murphy-Alford, A.J., Loechl, C., Luke, A.H., Rood, J., Schoeller, D.A., Westerterp, K.R., Wong, W.W., Speakman, J.R., Pontzer, H. 2022. Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition. Nature Communications. 13(1):99. https://doi.org/10.1038/s41467-021-27246-z.
DOI: https://doi.org/10.1038/s41467-021-27246-z

Interpretive Summary: This analysis of the largest collection of repeated measures of total daily energy expenditure was conducted in 348 adults and 47 children. The focus of the analysis was how energy expenditure changes in association with changes in body weight and composition. The repeatability of energy expenditure measurements was high in adults (not so in children). These findings suggest that low total energy expenditure is not a risk factor for weight gain, and that high energy expenditure is not protective against weight gain. These results address controversies in the literature on the role of energy expenditure in weight management.

Technical Abstract: Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean+/-SD time interval: 1.9 +/- 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass predicts changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but not children. Bivariate Bayesian mixed models show no among or within-individual correlation between body composition (fat mass or percentage) and unadjusted TEE in adults. For adults aged 20 - 60 y (N = 267; time interval: 7.4 +/-12.2 weeks), increases in adjusted TEE are associated with weight gain but not with changes in body composition; results are similar for subjects with intervals >4 weeks (N=53; 29.1+/- 12.8 weeks). This suggests low TEE is not a risk factor for, and high TEE is not protective against, weight or body fat gain over the time intervals tested.