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ARS Home » Southeast Area » New Orleans, Louisiana » Southern Regional Research Center » Commodity Utilization Research » Research » Publications at this Location » Publication #389680
Research Project: Development of Novel Cottonseed Products and Processes

Location: Commodity Utilization Research

Title: The hepatoprotective effects of plant-based foods based on the “gut–liver axis”: A prospective review

Author
item HU, QIONGDAN - Chengdu University Of Traditional Chinese Medicine
item LIAO, WAN - Chengdu University Of Traditional Chinese Medicine
item ZHANG, ZHEN - Chengdu University Of Traditional Chinese Medicine
item SHI, SANJUN - Chengdu University Of Traditional Chinese Medicine
item HOU, SHUGUANG - Chengdu University Of Traditional Chinese Medicine
item JI, NINGPING - Chengdu University Of Traditional Chinese Medicine
item ZHANG, XINJIE - Chengdu University Of Traditional Chinese Medicine
item ZHANG, QIAN - Chengdu University Of Traditional Chinese Medicine
item LIAO, YANGYANG - Chengdu University Of Traditional Chinese Medicine
item LI, LINGHUI - Chengdu University Of Traditional Chinese Medicine
item ZHU, ZONGPING - Chengdu University Of Traditional Chinese Medicine
item CHEN, YI - Chengdu University Of Traditional Chinese Medicine
item CHEN, JIAO - Chengdu University Of Traditional Chinese Medicine
item YU, FANGKUN - Chengdu University Of Traditional Chinese Medicine
item YANG, QINGSONG - Chengdu University Of Traditional Chinese Medicine
item XIAO, HONGTAO - Chengdu University Of Traditional Chinese Medicine
item FU, CHAOMEI - Chengdu University Of Traditional Chinese Medicine
item DU, HENGJUN - University Of Massachusetts, Amherst
item WANG, QI - University Of Massachusetts, Amherst
item Cao, Heping
item XIAO, HANG - University Of Massachusetts
item LI, RUI - Chengdu University Of Traditional Chinese Medicine

Submitted to: Critical Reviews in Food Science and Nutrition
Publication Type: Literature Review
Publication Acceptance Date: 4/25/2022
Publication Date: 4/25/2022
Citation: Hu, Q., Liao, W., Zhang, Z., Shi, S., Hou, S., Ji, N., Zhang, X., Zhang, Q., Liao, Y., Li, L., Zhu, Z., Chen, Y., Chen, J., Yu, F., Yang, Q., Xiao, H., Fu, C., Du, H., Wang, Q., Cao, H., Xiao, H., Li, R. 2022. The hepatoprotective effects of plant-based foods based on the “gut–liver axis”: A prospective review. Critical Reviews in Food Science and Nutrition. 2064423. https://doi.org/10.1080/10408398.2022.2064423.
DOI: https://doi.org/10.1080/10408398.2022.2064423

Interpretive Summary: The importance of the “gut–liver axis” in the pathogenesis of liver diseases has been revealed recently; which promotes the process of developing preventive and therapeutic strategies. However, considering that there are still many challenges in the diagnosis and medical treatment of liver diseases, potential preventive dietary intervention may be a good alternative choice. Plant-based foods have received much attention due to their reported efficacy in targeting multiple pathways involved in the pathogenesis of liver diseases as well as the relative safety for general use. Based on the PubMed and Web of Science databases, this review emphatically analyzes the plant-based foods especially in Eastern Asian diet and their chemical constituents with reported effects to impact the LPS/TLR4 signaling pathway of gut–liver axis of various liver diseases, reflecting their potential clinical applications in preventing/treating liver diseases. Some plant-based foods with the potential gut–liver effects are specifically discussed based on the reported research. This review intends to provide readers an overview of the current progress in the field of this research topic. We expect to see more emerging measures for alleviating the current prevalence of liver diseases.

Technical Abstract: The importance of the “gut–liver axis” in the pathogenesis of liver diseases has been revealed recently; which promotes the process of developing preventive and therapeutic strategies. However, considering that there are still many challenges in the diagnosis and medical treatment of liver diseases, potential preventive dietary intervention may be a good alternative choice. Plant-based foods have received much attention due to their reported efficacy in targeting multiple pathways involved in the pathogenesis of liver diseases as well as the relative safety for general use. Based on the PubMed and Web of Science databases, this review emphatically analyzes the plant-based foods especially in Eastern Asian diet and their chemical constituents with reported effects to impact the LPS/TLR4 signaling pathway of gut–liver axis of various liver diseases, reflecting their potential clinical applications in preventing/treating liver diseases. Some plant-based foods with the potential gut–liver effects are specifically discussed based on the reported research. This review intends to provide readers an overview of the current progress in the field of this research topic. We expect to see more emerging measures for alleviating the current prevalence of liver diseases.