Perspective: Dietary biomarkers of intake and exposure-exploration with omics approaches

Authors: MARUVADA, PADMA - National Institutes Of Health (NIH); LAMPE, JOHANNA - Fred Hutchinson Cancer Research Center; WISHART, DAVID - University Of Alberta; BARUPAL, DINESH - University Of California, Davis; CHESTER, DEIRDRA - National Institutes Of Health (NIH); DODD, DYLAN - Stanford University School Of Medicine; DJOUMBOU-FEUNANG, YANNICK - University Of Alberta; DORRESTEIN, PIETER - University Of California, San Diego; DRAGSTED, LARS - University Of Copenhagen; DRAPER, JOHN - Aberystwyth University; DUFFY, LINDA - National Institutes Of Health (NIH); DWYER, JOHANNA - National Institutes Of Health (NIH); EMENAKER, NANCY - National Institutes Of Health (NIH); FIEHN, OLIVER - University Of California, Davis; GERSZTEN, ROBERT - Harvard Medical School; HU, FRANK - Harvard School Of Public Health; KARP, ROBERT - National Institutes Of Health (NIH); Klurfeld, David; LAUGHLIN, MAREN - National Institutes Of Health (NIH); LITTLE, ROGER - National Institutes Of Health (NIH); LYNCH, CHRISTOPHER - National Institutes Of Health (NIH); MOORE, STEVEN - National Institutes Of Health (NIH); NICASTRO, HOLLY - National Institutes Of Health (NIH); O'BRIEN, DIANE - University Of Alaska; ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University; OSGANIAN, STRAVROULA - National Institutes Of Health (NIH); PLAYDON, MARY - University Of Utah; PRENTICE, ROSS - Fred Hutchinson Cancer Research Center; RAFTERY, DANIEL - Fred Hutchinson Cancer Research Center; REISDORPH, NICHOLE - University Of Colorado; ROCHE, HELEN - University Of Dublin; ROSS, SHARON - National Institutes Of Health (NIH); SANG, SHENGMIN - North Carolina State University; SCALBERT, AUGUSTIN - International Agency For Research On Cancer; SRINIVAS, POTHUR - National Institutes Of Health (NIH); ZEISEL, STEVEN - University Of North Carolina

Submitted to: Advances in Nutrition
Publication Type: Review Article
Publication Acceptance Date: 6/12/2019
Publication Date: 8/6/2019
Citation: Maruvada, P., Lampe, J.W., Wishart, D.S., Barupal, D., Chester, D.N., Dodd, D., Djoumbou-Feunang, Y., Dorrestein, P.C., Dragsted, L.O., Draper, J., Duffy, L.C., Dwyer, J.T., Emenaker, N.J., Fiehn, O., Gerszten, R.E., Hu, F.B., Karp, R.W., Klurfeld, D.M., Laughlin, M.R., Little, R.A., Lynch, C.J., Moore, S.C., Nicastro, H.L., O'Brien, D.M., Ordovas, J.M., Osganian, S.K., Playdon, M., Prentice, R., Raftery, D., Reisdorph, N., Roche, H.M., Ross, S.M., Sang, S., Scalbert, A., Srinivas, P.R., Zeisel, S.M. 2019. Perspective: Dietary biomarkers of intake and exposure-exploration with omics approaches. Advances in Nutrition. 11(2):200-215. https://doi.org/10.1093/advances/nmz075.
DOI: https://doi.org/10.1093/advances/nmz075

Interpretive Summary:

Technical Abstract: While conventional nutrition research has yielded biomarkers such as doubly labeled water for energy metabolism and 24-h urinary nitrogen for protein intake, a critical need exists for additional, equally robust biomarkers that allow for objective assessment of specific food intake and dietary exposure. Recent advances in high-throughput MS combined with improved metabolomics techniques and bioinformatic tools provide new opportunities for dietary biomarker development. In September 2018, the NIH organized a 2-d workshop to engage nutrition and omics researchers and explore the potential of multiomics approaches in nutritional biomarker research. The current Perspective summarizes key gaps and challenges identified, as well as the recommendations from the workshop that could serve as a guide for scientists interested in dietary biomarkers research. Topics addressed included study designs for biomarker development, analytical and bioinformatic considerations, and integration of dietary biomarkers with other omics techniques. Several clear needs were identified, including larger controlled feeding studies, testing a variety of foods and dietary patterns across diverse populations, improved reporting standards to support study replication, more chemical standards covering a broader range of food constituents and human metabolites, standardized approaches for biomarker validation, comprehensive and accessible food composition databases, a common ontology for dietary biomarker literature, and methodologic work on statistical procedures for intake biomarker discovery. Multidisciplinary research teams with appropriate expertise are critical to moving forward the field of dietary biomarkers and producing robust, reproducible biomarkers that can be used in public health and clinical research.