The unsung roles of microbial secondary metabolite effectors in the plant disease cacophony

Authors: Rangel, Lorena; Bolton, Melvin

Submitted to: Current Opinion in Plant Biology
Publication Type: Review Article
Publication Acceptance Date: 5/2/2022
Publication Date: 6/6/2022
Citation: Rangel, L., Bolton, M.D. 2022. The unsung roles of microbial secondary metabolite effectors in the plant disease cacophony. Current Opinion in Plant Biology. 68. Article e102233. https://doi.org/10.1016/j.pbi.2022.102233.
DOI: https://doi.org/10.1016/j.pbi.2022.102233

Interpretive Summary:

Technical Abstract: Plants counter disease with an array of responses to styme pathogen ingress. In contrast to this cacophony, plant pathogens orchestrate a finely tuned repertoire of virulence mechanisms in their attempt to cause disease. One such example is the production of secondary metabolite effectors (SMEs). Despite many attempts to functionally categorize SMEs, their many roles in plant disease have proven they march to the beat of their producer's drum. Some lesser studied features of SMEs in plant disease include self-resistance (SR) and manipulation of the microbiome to enhance pathogen virulence. SR can be accomplished in three general compositions, with the first being the transport of the SME to a benign location; the second being modification of the SME so it cannot harm the producer; and the third being metabolic regulation of the SME or the producer homolog of the SME target. SMEs may also play an interlude prior to disease by shaping the plant microbial community, allowing producers to better establish themselves. Taken together, SMEs are integral players in the phytopathology canon.