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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #391041
Research Project: Nutrition, Sarcopenia, Physical Function, and Skeletal Muscle Capacity During Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Identifying biomarkers for biological age: geroscience and the ICFSR task force

Author
item LEBRASSEUR, NATHAN - Mayo Clinic
item DE CABO, RAFAEL - National Institute On Aging (NIA, NIH)
item FIELDING, ROGER - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item FERRUCCI, LUIGI - National Institute On Aging (NIA, NIH)
item RODRIGUEZ-MANAS, LEOCADIO - Hospital Universitario De Getafe
item VINA, JOSE - University Of Valencia
item VELLAS, BRUNO - Toulouse University Hospital

Submitted to: The Journal of Frailty and Aging
Publication Type: Review Article
Publication Acceptance Date: 2/2/2021
Publication Date: 3/8/2021
Citation: Lebrasseur, N.K., De Cabo, R., Fielding, R.A., Ferrucci, L., Rodriguez-Manas, L., Vina, J., Vellas, B. 2021. Identifying biomarkers for biological age: geroscience and the ICFSR task force. The Journal of Frailty and Aging. 10:196-201. https://doi.org/10.14283/jfa.2021.5.
DOI: https://doi.org/10.14283/jfa.2021.5

Interpretive Summary:

Technical Abstract: The International Conference on Frailty and Sarcopenia Research Task Force met in March 2020, in the shadow of the COVID-19 pandemic, to discuss strategies for advancing the interdisciplinary field of geroscience. Geroscience explores biological mechanisms of aging as targets for intervention that may delay the physiological consequences of aging, maintain function, and prevent frailty and disability. Priorities for clinical practice and research include identifying and validating a range of biomarkers of the hallmarks of aging. Potential biomarkers discussed included markers of mitochondrial dysfunction, proteostasis, stem cell dysfunction, nutrient sensing, genomic instability, telomere dysfunction, cellular senescence, and epigenetic changes. The FRAILOMICS initiative is exploring many of these through various omics studies. Translating this knowledge into new therapies is being addressed by the U.S. National Institute on Aging Translational Gerontology Branch. Research gaps identified by the Task Force include the need for improved cellular and animal models as well as more reliable and sensitive measures.