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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #391046
Research Project: Personalized Nutrition and Healthy Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study

Author
item RANGEL-ZUNIGA, ORIOL - University Hospital Reina Sofia
item VALS-DELGADO, CRISTINA - University Hospital Reina Sofia
item ALCALA-DIAZ, JUAN - University Hospital Reina Sofia
item QUINTANA-NAVARRO, GRACIA - University Hospital Reina Sofia
item KRYLOVA, YELIZAVETA - University Hospital Reina Sofia
item LEON-ACUNA, ANA - University Hospital Reina Sofia
item LUQUE, RAUL - Maimonides Biomedical Research Institute Of Cordoba (IMIBIC)
item GOMEZ-DELGADO, FRANCISCO - University Hospital Reina Sofia
item DELGADO-LISTA, JAVIER - University Hospital Reina Sofia
item ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item PEREZ-MARTINEZ, PABLO - University Hospital Reina Sofia
item CAMARGO, ANTONIO - University Hospital Reina Sofia
item LOPEZ-MIRANDA, JOSE - University Hospital Reina Sofia

Submitted to: Molecular Therapy - Nucleic Acids
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/5/2020
Publication Date: 11/10/2020
Citation: Rangel-Zuniga, O.A., Vals-Delgado, C., Alcala-Diaz, J.F., Quintana-Navarro, G., Krylova, Y., Leon-Acuna, A., Luque, R.M., Gomez-Delgado, F., Delgado-Lista, J., Ordovas, J.M., Perez-Martinez, P., Camargo, A., Lopez-Miranda, J. 2020. A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study. Molecular Therapy - Nucleic Acids. 23:255-263. https://doi.org/10.1016/j.omtn.2020.11.001.
DOI: https://doi.org/10.1016/j.omtn.2020.11.001

Interpretive Summary: MicroRNAs (miRNAs) are small RNA molecules found in plants, animals, and some viruses, that function in the silencing of larger RNAs and thus, regulate the expression of genes. Their abundances have been associated with a higher or lower risk of diseases, such as type 2 diabetes mellitus (T2DM). However, the use of miRNAs to predict T2DM remission has not been investigated. Therefore, investigators at the HNRCA in Boston, in collaboration with Spanish researchers, examined whether blood circulating miRNAs could be used to predict the probability of T2DM remission in patients with coronary heart disease. For this purpose, miRNAs in blood were measured in 190 newly diagnosed T2DM patients participating in the CORDIOPREV study. Seven miRNAs were identified as potential predictors of T2DM remission. These miRNAs had the potential to regulate 26 genes. Therefore, this study has identified new biological predictors of dietary remission of T2DM. This new information could be used for predictive and therapeutic purposes in Precision Medicine and Nutrition.

Technical Abstract: MicroRNAs (miRNAs) regulate the expression of genes associated with the development of diseases, including type 2 diabetes mellitus (T2DM). However, the use of miRNAs to predict T2DM remission has been poorly studied. Therefore, we aimed to investigate whether circulating miRNAs could be used to predict the probability of T2DM remission in patients with coronary heart disease. We included the newly diagnosed T2DM (n = 190) of the 1,002 patients from the CORDIOPREV study. Seventy-three patients reverted from T2DM after 5 years of dietary intervention with a low-fat or Mediterranean diet. Plasma levels of 56 miRNAs were measured by OpenArray. Generalized linear model, receiver operating characteristic (ROC), Cox regression, and pathway analyses were performed. ROC analysis based on clinical variables showed an area under the curve (AUC) of 0.66. After a linear regression analysis, seven miRNAs were identified as the most important variables in the group's differentiation. The addition of these miRNAs to clinical variables showed an AUC of 0.79. Cox regression analysis using a T2DM remission score including miRNAs showed that high-score patients have a higher probability of T2DM remission (hazard ratio [HR]low versus high, 4.44). Finally, 26 genes involved in 10 pathways were related to the miRNAs. We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease.