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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #393862
Research Project: Nutrition, Sarcopenia, Physical Function, and Skeletal Muscle Capacity During Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Exercise intolerance in older adults with heart failure with preserved ejection fraction: JACC state-of-the-art review

Author
item PANDEY, AMBARISH - UNIVERSITY OF TEXAS
item SHAH, SANJIV - NORTHWESTERN UNIVERSITY
item BUTLER, JAVED - UNIVERSITY OF MISSISSIPPI
item KELLOGG, JR., DEAN - UNIVERSITY OF TEXAS
item LEWIS, GREGORY - MASSACHUSETTS GENERAL HOSPITAL
item FORMAN, DANIEL - UNIVERSITY OF PITTSBURGH
item MENTZ, ROBERT - DUKE UNIVERSITY
item BORLAUG, BARRY - MAYO CLINIC
item SIMON, MARC - UNIVERSITY OF PITTSBURGH
item CHIRINOS, JULIO - UNIVERSITY OF PENNSYLVANIA
item FIELDING, ROGER - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY
item VOLPI, ELENA - UNIVERSITY OF TEXAS
item MOLINA, ANTHONY - UNIVERSITY OF CALIFORNIA (UCLA)
item HAYKOWSKY, MARK - UNIVERSITY OF ALBERTA
item SAM, FLORA - BOSTON UNIVERSITY
item GOODPASTER, BRET - ADVENTHEALTH TRANSLATIONAL RESEARCH INSTITUTE FOR METABOLISM AND DIABETES
item BERTONI, ALAIN - WAKE FOREST SCHOOL OF MEDICINE
item JUSTICE, JAMIE - WAKE FOREST SCHOOL OF MEDICINE
item WHITE, JAMES - DUKE UNIVERSITY
item DING, JINGZHONG - WAKE FOREST SCHOOL OF MEDICINE
item HUMMEL, SCOTT - UNIVERSITY OF MICHIGAN
item LEBRASSEUR, NATHAN - MAYO CLINIC
item TAFFET, GEORGE - BAYLOR COLLEGE OF MEDICINE
item PIPINOS, IRAKLIS - UNIVERSITY OF NEBRASKA
item KITZMAN, DALANE - WAKE FOREST SCHOOL OF MEDICINE

Submitted to: Journal of the American College of Cardiology
Publication Type: Review Article
Publication Acceptance Date: 7/13/2021
Publication Date: 9/6/2021
Citation: Pandey, A., Shah, S.J., Butler, J., Kellogg, Jr., D.L., Lewis, G.D., Forman, D., Mentz, R.J., Borlaug, B.A., Simon, M.A., Chirinos, J.A., Fielding, R.A., Volpi, E., Molina, A.J., Haykowsky, M.J., Sam, F., Goodpaster, B.H., Bertoni, A.G., Justice, J.N., White, J.P., Ding, J., Hummel, S.L., Lebrasseur, N.K., Taffet, G.E., Pipinos, I.I., Kitzman, D.W. 2021. Exercise intolerance in older adults with heart failure with preserved ejection fraction: JACC state-of-the-art review. Journal of the American College of Cardiology. 78(11):1166-1187. https://doi.org/10.1016/j.jacc.2021.07.014.
DOI: https://doi.org/10.1016/j.jacc.2021.07.014

Interpretive Summary:

Technical Abstract: Exercise intolerance (EI) is the primary manifestation of chronic heart failure with preserved ejection fraction (HFpEF), the most common form of heart failure among older individuals. The recent recognition that HFpEF is likely a systemic, multiorgan disorder that shares characteristics with other common, difficult-to-treat, aging-related disorders suggests that novel insights may be gained from combining knowledge and concepts from aging and cardiovascular disease disciplines. This state-of-the-art review is based on the outcomes of a National Institute of Aging-sponsored working group meeting on aging and EI in HFpEF. We discuss aging-related and extracardiac contributors to EI in HFpEF and provide the rationale for a transdisciplinary, "gero-centric" approach to advance our understanding of EI in HFpEF and identify promising new therapeutic targets. We also provide a framework for prioritizing future research, including developing a uniform, comprehensive approach to phenotypic characterization of HFpEF, elucidating key geroscience targets for treatment, and conducting proof-of-concept trials to modify these targets.