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ARS Home » Plains Area » Clay Center, Nebraska » U.S. Meat Animal Research Center » Nutrition, Growth and Physiology » Research » Publications at this Location » Publication #394683
Research Project: Improve Nutrient Management and Efficiency of Beef Cattle and Swine

Location: Nutrition, Growth and Physiology

Title: Vitamin and mineral supplementation and rate of gain during the first trimester of gestation in heifers affect the fetal hepatic lipidome at d 83 of gestation

Author
item Crouse, Matthew
item MCCARTHY, KACIE - North Dakota State University
item WARD, ALISON - North Dakota State University
item BOROWICZ, PAWEL - North Dakota State University
item REYNOLDS, LARRY - North Dakota State University
item FORCHERIO, J - Purina
item SCOTT, R - Purina
item CATON, JOEL - North Dakota State University
item DAHLEN, CARL - North Dakota State University

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 6/22/2022
Publication Date: 8/28/2022
Citation: Crouse, M.S., McCarthy, K., Ward, A., Borowicz, P., Reynolds, L., Forcherio, J., Scott, R., Caton, J., Dahlen, C. 2022. Vitamin and mineral supplementation and rate of gain during the first trimester of gestation in heifers affect the fetal hepatic lipidome at d 83 of gestation [abstract]. 2022 Aspen Perinatal Biology Symposium. Abstract I-I (Scientific Program p. 22). Available: https://www.asas.org/meetings/perinatal-biology-symposium-2022/scientific-program-(draft)

Interpretive Summary:

Technical Abstract: Objectives: The objective of this study was to evaluate the effects of feeding heifers a vitamin and mineral supplement and targeting divergent rates of gain during early gestation on the fetal liver lipidome at d 83 of gestation. Methods: Seventy-two crossbred Angus heifers were randomly assigned in a 2 × 2 factorial arrangement to one of four treatments comprising the main effects of vitamin and mineral supplementation (VTM or NOVTM) and feeding to achieve different rates of gain (low gain [LG] 0.28 kg/d, vs. moderate gain [MG] 0.79 kg/d). To achieve the different rates of gain, MG heifers received a protein/energy supplement that contained fish oil as a component of the supplement. Thirty-five gestating heifers with female fetuses were ovariohysterectomized on d 83 of gestation, and fetal liver was collected and analyzed by Metabolon Inc. Results: Polyunsaturated fatty acids (PUFA) were increased (P < 0.05) in fetal liver of MG vs. LG heifers. The concentrations of nearly all acyl carnitines measured were decreased (P < 0.05) in fetal liver of VTM-LG and NoVTM-MG compared with NOVTM-LG and VTM-MG heifers; however, there were no differences in acetyl-CoA, ketones, or metabolites in the TCA cycle. Conclusions: These results demonstrate that bovine fetal livers accumulate PUFA which is consistent with prior research and has demonstrated positive growth responses in ruminants. Furthermore, acyl carnitines are differentially responsive to maternal vitamin/ mineral status and energy/protein intake; however, without a response in other markers of energy or fatty acid metabolism, these data suggest that energy balance of fetal livers across treatments remains relatively stable. (Funding: NIFA #2018-67011-31708).