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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #395645
Research Project: Personalized Nutrition and Healthy Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-plus study

Author
item BECERRA-TOMAS, NEREA - University Rovira I Virgili
item MENA-SANCHEZ, GUILLERMO - University Rovira I Virgili
item DIAZ-LOPEZ, ANDRES - University Rovira I Virgili
item MARTINEZ-GONZALEZ, MIGUEL - Instituto De Salud Carlos Iii
item BABIO, NANCY - University Rovira I Virgili
item CORELLA, DOLORES - Instituto De Salud Carlos Iii
item FREIXER, GALA - Hospital Del Mar Medical Research Institute
item ROMAGUERA, DORA - Instituto De Salud Carlos Iii
item VIOQUE, JESUS - Instituto De Salud Carlos Iii
item ALONSO-GOMEZ, ANGEL - Instituto De Salud Carlos Iii
item WARNBERG, JULIA - Instituto De Salud Carlos Iii
item MARTINEZ, J. ALFREDO - Instituto De Salud Carlos Iii
item SERRA-MAJEM, LLUIS - Instituto De Salud Carlos Iii
item ESTRUCH, RAMON - Instituto De Salud Carlos Iii
item FERNANDEZ-GARCIA, JOSE - Instituto De Salud Carlos Iii
item LAPETRA, JOSE - Instituto De Salud Carlos Iii
item PINTO, XAVIER - Instituto De Salud Carlos Iii
item TUR, JOSEP - Instituto De Salud Carlos Iii
item LOPEZ-MIRANDA, JOSE - Instituto De Salud Carlos Iii
item BUENO-CAVANILLAS, AURORA - Instituto De Salud Carlos Iii
item GAFORIO, JOSE - Instituto De Salud Carlos Iii
item MATIA-MARTIN, PILAR - Health Research Institute Of The San Carlos Clinical Hospital
item DAIMIEL, LIDIA - Imdea Food
item MATIA-SANCHEZ, VICENTE - Instituto De Salud Carlos Iii
item VIDAL, JOSEP - Instituto De Salud Carlos Iii
item VAZQUEZ, CLOTILDE - Instituto De Salud Carlos Iii
item ROS, EMILI - Instituto De Salud Carlos Iii
item RAZQUIN, CRISTINA - Instituto De Salud Carlos Iii
item ABELLAN CANO, IVAN - University Rovira I Virgili
item SORLI, JOSE - Instituto De Salud Carlos Iii
item TORRES, LAURA - Hospital Del Mar Medical Research Institute
item MOREY, MARGA - Instituto De Salud Carlos Iii
item NAVARRETE-MUNO, EVA - Instituto De Salud Carlos Iii
item TOJAL SIERRA, LUCAS - Instituto De Salud Carlos Iii
item CRESPO-OLIVA, EDELYS - Instituto De Salud Carlos Iii
item ZULET, M. ANGELES - Instituto De Salud Carlos Iii
item SANCHEZ-VILLEGAS, ALMUDENA - Instituto De Salud Carlos Iii
item CASAS, ROSA - Instituto De Salud Carlos Iii
item BERNAL-LOPEZ, M. ROSA - Instituto De Salud Carlos Iii
item SANTOS-LOZANO, JOSE MANUEL - Instituto De Salud Carlos Iii
item CORBELLA, EMILI - Instituto De Salud Carlos Iii
item DEL MAR BIBILONI, MARIA - Instituto De Salud Carlos Iii
item RUIZ-CANELA, MIGUEL - Instituto De Salud Carlos Iii
item FERNANDEZ-CARRION, REBECA - Instituto De Salud Carlos Iii
item QUIFER, MIREIA - Hospital Del Mar Medical Research Institute
item PRIETO, RAFEL - Instituto De Salud Carlos Iii
item FERNANDEZ-BRUFAL, NOELIA - Instituto De Salud Carlos Iii
item SALAVERRIA LETE, ITZIAR - Hospital Universitario Araba
item CENOZ, JUAN CARLOS - University Of Navarra
item LLIMONA, REGINA - Hospital Del Mar Medical Research Institute
item SALAS-SALVADO, JORDI - University Rovira I Virgili
item ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: European Journal of Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/25/2019
Publication Date: 8/5/2019
Citation: Becerra-Tomas, N., Mena-Sanchez, G., Diaz-Lopez, A., Martinez-Gonzalez, M.A., Babio, N., Corella, D., Freixer, G., Romaguera, D., Vioque, J., Alonso-Gomez, A.M., Warnberg, J., Martinez, J., Serra-Majem, L., Estruch, R., Fernandez-Garcia, J., Lapetra, J., Pinto, X., Tur, J., Lopez-Miranda, J., Bueno-Cavanillas, A., Gaforio, J.J., Matia-Martin, P., Daimiel, L., Matia-Sanchez, V., Vidal, J., Vazquez, C., Ros, E., Razquin, C., Abellan Cano, I., Sorli, J.V., Torres, L., Morey, M., Navarrete-Muno, E.M., Tojal Sierra, L., Crespo-Oliva, E., Zulet, M., Sanchez-Villegas, A., Casas, R., Bernal-Lopez, M., Santos-Lozano, J., Corbella, E., del Mar Bibiloni, M., Ruiz-Canela, M., Fernandez-Carrion, R., Quifer, M., Prieto, R.M., Fernandez-Brufal, N., Salaverria Lete, I., Cenoz, J., Llimona, R., Salas-Salvado, J., Ordovas, J.M. 2019. Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-plus study. European Journal of Nutrition. https://doi.org/10.1007/s00394-019-02070-W.
DOI: https://doi.org/10.1007/s00394-019-02070-W

Interpretive Summary: High blood levels of uric acid (hyperuricemia) increase not only the risk of gout, but also metabolic syndrome, type 2 diabetes, hypertension and cardiovascular disease (CVD). Therefore, strategies focused on decreasing the levels of blood uric acid could be important to reduce the global burden of these cardiometabolic diseases. Therefore, the purpose of the study was to assess the association between the consumption of non-soy legumes and different subtypes of non-soy legumes and blood uric acid in elderly individuals with overweight or obesity and metabolic syndrome. This was done in the context of the PREDIMED-Plus study including 6329 participants. These analyses were conducted by investigators in Spain and at the HNRCA in Boston. The results demonstrate that in elderly subjects with metabolic syndrome, the consumption of non-soy legumes (e.g., lentils, chickpeas, dry beans and peas) was inversely associated with blood uric acid levels and hyperuricemia prevalence. These findings add new insights about the potential beneficial role of non-soy legumes on uric acid levels and hyperuricemia risk and could inform future evidence-based dietary guidelines for hyperuricemia prevention.

Technical Abstract: PURPOSE: To assess the association between the consumption of non-soy legumes and different subtypes of non-soy legumes and serum uric acid (SUA) or hyperuricemia in elderly individuals with overweight or obesity and metabolic syndrome. METHODS: A cross-sectional analysis was conducted in the framework of the PREDIMED-Plus study. We included 6329 participants with information on non-soy legume consumption and SUA levels. Non-soy legume consumption was estimated using a semi-quantitative food frequency questionnaire. Linear regression models and Cox regression models were used to assess the associations between tertiles of non-soy legume consumption, different subtypes of non-soy legume consumption and SUA levels or hyperuricemia prevalence, respectively. RESULTS: Individuals in the highest tertile (T3) of total non-soy legume, lentil and pea consumption, had 0.14 mg/dL, 0.19 mg/dL and 0.12 mg/dL lower SUA levels, respectively, compared to those in the lowest tertile (T1), which was considered the reference one. Chickpea and dry bean consumption showed no association. In multivariable models, participants located in the top tertile of total non-soy legumes [prevalence ratio (PR): 0.89; 95% CI 0.82-0.97; p trend = 0.01, lentils (PR: 0.89; 95% CI 0.82-0.97; p trend = 0.01), dry beans (PR: 0.91; 95% C: 0.84-0.99; p trend = 0.03) and peas (PR: 0.89; 95% CI 0.82- .97; p trend = 0.01)] presented a lower prevalence of hyperuricemia (vs. the bottom tertile). Chickpea consumption was not associated with hyperuricemia prevalence. CONCLUSIONS: In this study of elderly subjects with metabolic syndrome, we observed that despite being a purine-rich food, non-soy legumes were inversely associated with SUA levels and hyperuricemia prevalence.