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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #395759
Research Project: Personalized Nutrition and Healthy Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Genetic biomarkers of metabolic detoxification for personalized lifestyle medicine

Author
item ARONICA, LUCIA - Metagenics, Inc
item ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item VOLKOV, ANDREY - Bennet Data Sciences
item LAMB, JOSEPH - Personalized Lifestyle Medicine Center
item STONE, PETER MICHAEL - Personalized Lifestyle Medicine Center
item MINICH, DEANNA - Institute For Functional Medicine Federal Way
item LEARY, MICHELLE - Vida Integrated Health
item CLASS, MONIQUE - Institute For Functional Medicine Federal Way
item METTI, DINA - Personalized Lifestyle Medicine Center
item LARSON, ILONA - Metagenics, Inc
item CONTRACTOR, NIKHAT - Nutrilite Health Institute
item ECK, BRENT - Metagenics, Inc
item BLAND, JEFFREY - Personalized Lifestyle Medicine Center

Submitted to: Nutrients
Publication Type: Review Article
Publication Acceptance Date: 2/8/2022
Publication Date: 2/11/2022
Citation: Aronica, L., Ordovas, J.M., Volkov, A., Lamb, J.J., Stone, P., Minich, D.M., Leary, M., Class, M., Metti, D., Larson, I.A., Contractor, N., Eck, B., Bland, J. 2022. Genetic biomarkers of metabolic detoxification for personalized lifestyle medicine. Nutrients. https://doi.org/10.3390/nu14040768.
DOI: https://doi.org/10.3390/nu14040768

Interpretive Summary:

Technical Abstract: Metabolic detoxification (detox)-or biotransformation-is a physiological function that removes toxic substances from our body. Genetic variability and dietary factors may affect the function of detox enzymes, thus impacting the body's sensitivity to toxic substances of endogenous and exogenous origin. From a genetic perspective, most of the current knowledge relies on observational studies in humans or experimental models in vivo and in vitro, with very limited proof of causality and clinical value. This review provides health practitioners with a list of single nucleotide polymorphisms (SNPs) located within genes involved in Phase I and Phase II detoxification reactions, for which evidence of clinical utility does exist. We have selected these SNPs based on their association with interindividual variability of detox metabolism in response to certain nutrients in the context of human clinical trials. In order to facilitate clinical interpretation and usage of these SNPs, we provide, for each of them, a strength of evidence score based on recent guidelines for genotype-based dietary advice. We also present the association of these SNPs with functional biomarkers of detox metabolism in a pragmatic clinical trial, the LIFEHOUSE study.