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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #395930
Research Project: Personalized Nutrition and Healthy Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Diabetes remission is modulated by branched chain amino acids according to the diet consumed: From the CORDIOPREV Study

Author
item CARDELO, MAGDALENA - University Hospital Reina Sofia
item ALCALA-DIAZ, JUAN - University Hospital Reina Sofia
item GUTIERREZ-MARISCAL, FRANCISCO - University Hospital Reina Sofia
item LOPEZ-MORENO, JAVIER - University Hospital Reina Sofia
item VILLASANTA-GONZALEZ, ALEJANDRO - University Hospital Reina Sofia
item ARENAS-DE LARRIVA, ANTONIO - University Hospital Reina Sofia
item DE LA CRUZ-ARES, SILVIA - University Hospital Reina Sofia
item DELGADO-LISTA, JAVIER - University Hospital Reina Sofia
item RODRIGUEZ-CANTALEJO, FERNANDO - University Hospital Reina Sofia
item LUQUE, RAUL - Maimonides Biomedical Research Institute Of Cordoba (IMIBIC)
item ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item PEREZ-MARTINEZ, PABLO - University Hospital Reina Sofia
item CAMARGO, ANTONIO - University Hospital Reina Sofia
item LOPEZ-MIRANDA, JOSE - University Hospital Reina Sofia

Submitted to: Molecular Nutrition and Food Research
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/24/2021
Publication Date: 1/7/2022
Citation: Cardelo, M.P., Alcala-Diaz, J.F., Gutierrez-Mariscal, F.M., Lopez-Moreno, J., Villasanta-Gonzalez, A., Arenas-De Larriva, A., De La Cruz-Ares, S., Delgado-Lista, J., Rodriguez-Cantalejo, F., Luque, R.M., Ordovas, J., Perez-Martinez, P., Camargo, A., Lopez-Miranda, J. 2022. Diabetes remission is modulated by branched chain amino acids according to the diet consumed: From the CORDIOPREV Study. Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.202100652.
DOI: https://doi.org/10.1002/mnfr.202100652

Interpretive Summary: Blood levels of a specific type of amino acid known as Branched Chain Amino Acids (BCAA) have been previously associated with type 2 diabetes mellitus (T2DM). Investigators at the HNRCA in Boston, in collaboration with Spanish investigators, aimed to investigate whether their levels could be predictors of T2DM remission following the consumption of a Mediterranean diet (Med) or a low-fat (LF) diet. The analyses of these BCAAs in the CORDIOPREV study suggest that their measurement could potentially be used to select the most suitable diet to induce T2DM remission by nutritional strategies in cardiovascular patients.

Technical Abstract: SCOPE: Branched Chain Amino Acids (BCAA) plasma levels may be differentially associated with type 2 diabetes mellitus (T2DM) remission through the consumption of the Mediterranean diet (Med) and a low-fat (LF) diet. METHODS: One hundred eighty-three newly diagnosed T2DM patients within the CORDIOPREV study are randomized to consume the Med or a LF diet. BCAA plasma levels (isoleucine, leucine, and valine) are measured at fasting and after 120 min of an oral glucose tolerance test (OGTT) at the baseline of the study and after 5 years of the dietary intervention. RESULTS: Isoleucine, leucine, and valine plasma levels after 120 min of an OGTT in the Med diet (N = 80) are associated by COX analysis with T2DM remission: HR per SD (95% CI): 0.53 (0.37-0.77), 0.75 (0.52-1.08), and 0.61 (0.45-0.82), respectively; no association is found in patients who consumed a LF diet (N = 103). BCAA plasma levels combined in a score show a HR of 3.33 (1.55-7.19) of T2DM remission for patients with a high score values in the Med diet, while in those with a LF diet, no association is found. CONCLUSION: The study suggests that BCAA measurements potentially be used as a tool to select the most suitable diet to induce T2DM remission by nutritional strategies.