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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #396119
Research Project: Personalized Nutrition and Healthy Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: A microbiota-based predictive model for type 2 diabetes remission induced by dietary intervention: From the CORDIOPREV study

Author
item VALS-DELGADO, CRISTINA - University Hospital Reina Sofia
item ALCALA-DIAZ, JUAN - University Hospital Reina Sofia
item RONCERO-RAMOS, IRENE - University Hospital Reina Sofia
item LEON-ACUNA, ANA - University Hospital Reina Sofia
item MOLINA-ABRIL, HELENA - University Of Seville
item GUTIERREZ-MARISCAL, FRANCISCO - University Hospital Reina Sofia
item ROMERO-CABRERA, JUAN - University Hospital Reina Sofia
item DE LA CRUZ-ARES, SILVIA - University Hospital Reina Sofia
item VAN OMMEN, BEN - Netherlands Institute For Applied Science
item CASTANO, JUSTO - Instituto De Salud Carlos Iii
item ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item PEREZ-MARTINEZ, PABLO - University Hospital Reina Sofia
item DELGADO-LISTA, JAVIER - University Hospital Reina Sofia
item CAMARGO, ANTONIO - University Hospital Reina Sofia
item LOPEZ-MIRANDA, JOSE - University Hospital Reina Sofia

Submitted to: Clinical and Translational Medicine
Publication Type: Other
Publication Acceptance Date: 1/31/2021
Publication Date: 4/6/2021
Citation: Vals-Delgado, C., Alcala-Diaz, J.F., Roncero-Ramos, I., Leon-Acuna, A., Molina-Abril, H., Gutierrez-Mariscal, F.M., Romero-Cabrera, J.L., De La Cruz-Ares, S., Van Ommen, B., Castano, J., Ordovas, J.M., Perez-Martinez, P., Delgado-Lista, J., Camargo, A., Lopez-Miranda, J. 2021. A microbiota-based predictive model for type 2 diabetes remission induced by dietary intervention: From the CORDIOPREV study. Clinical and Translational Medicine. 11(4):e326. https://doi.org/10.1002/ctm2.326.
DOI: https://doi.org/10.1002/ctm2.326

Interpretive Summary:

Technical Abstract: Type 2 diabetes is widely considered as a chronic, progressive disease that is a consequence of the seemingly inexorable decline in beta-cell function. However, recent studies have demonstrated that in the early stages of development, it may be reversible. Indeed, in this regard, primary support derived from patients undergoing bariatric surgery has provided the earliest evidence of type 2 diabetes remission. In fact, the normalization of plasma glucose levels can occur in some patients just days after bariatric surgical intervention, and even before achieving significant weight loss. This observation points to a relevant glucoregulatory role of the gastrointestinal tract. It has been proposed that a number of different, but not mutually exclusive, potential mechanisms may contribute toward this effect, including changes in bile acid metabolism, gastrointestinal tract nutrient sensing and glucose utilization, incretins, and gut microbiota.