Vitamin D from supplements consumed during infancy and toddlerhood and bone health: A systematic review

Authors: DEWEY, KATHRYN - University Of California, Davis; BAZZANO, LYDIA - Tulane University Medical Center; DAVIS, TERESA - Children'S Nutrition Research Center (CNRC); DONOVAN, SHARON - University Of Illinois; TAVERAS, ELSIE - Massachusetts General Hospital; KLEINMAN, RONALD - Massachusetts General Hospital

Submitted to: Government Publication/Report
Publication Type: Review Article
Publication Acceptance Date: 7/15/2020
Publication Date: 7/15/2020
Citation: Dewey, K., Bazzano, L., Davis, T., Donovan, S., Taveras, E., Kleinman, R. 2020. Vitamin D from supplements consumed during infancy and toddlerhood and bone health: A systematic review. 2020 Dietary Guidelines Advisory Committee Project. https://doi.org/10.52570/NESR.DGAC2020.SR0304.
DOI: https://doi.org/10.52570/NESR.DGAC2020.SR0304

Interpretive Summary:

Technical Abstract: Limited evidence suggests no relationship between consumption of 400 IU per day of vitamin D from supplements before age 12 months, compared with higher dosages of up to 1600 IU per day, and biomarkers of bone metabolism in children up to age 36 months. Insufficient evidence is available to determine the relationship between 400 IU per day of vitamin D from supplements, compared with higher dosages, and bone mass, rickets, or fracture.Insufficient evidence is available to determine the relationship between 400 IU per day of vitamin D from supplements, compared with lower dosages, and bone mass, biomarkers of bone metabolism, rickets, or fracture. Insufficient evidence is available to determine the relationship between vitamin D from supplements, compared with no vitamin D from supplements, and bone mass, biomarkers of bone metabolism, rickets, or fracture. Insufficient evidence is available to determine the relationship between vitamin D from supplements, compared with vitamin D from fortified foods, and bone mass, biomarkers of bone metabolism, rickets, or fracture.