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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #396363
Research Project: Personalized Nutrition and Healthy Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial

Author
item DAIMIEL, LIDIA - Imdea Institute
item MARTINEZ-GONZALEZ, MIGUEL - Instituto De Salud Carlos Iii
item CORELLA, DOLORES - Instituto De Salud Carlos Iii
item SALAS-SALVADO, JORDI - Instituto De Salud Carlos Iii
item SCHRODER, HELMUT - Instituto De Salud Carlos Iii
item VIOQUE, JESUS - Instituto De Salud Carlos Iii
item ROMAGUERA, DORA - Instituto De Salud Carlos Iii
item MARTINEZ, J - Instituto De Salud Carlos Iii
item WARNBERG, JULIA - Instituto De Salud Carlos Iii
item LOPEZ-MIRANDA, JOSE - Instituto De Salud Carlos Iii
item ESTRUCH, RAMON - Instituto De Salud Carlos Iii
item CANO-IBANEZ, NAOMI - Instituto De Salud Carlos Iii
item ALONSO-GOMEZ, ANGEL - Instituto De Salud Carlos Iii
item TUR, JOSEP - Instituto De Salud Carlos Iii
item TINAHONES, FRANCISCO - Instituto De Salud Carlos Iii
item SERRA-MAJEM, LLUIS - Instituto De Salud Carlos Iii
item MICO-PEREZ, RAFAEL - Miguel Hernandez University
item LAPETRA, JOSE - Instituto De Salud Carlos Iii
item GALDON, ALBA - Iis-Fundacion Jimenez Diaz
item PINTO, XAVIER - Instituto De Salud Carlos Iii
item VIDAL, JOSEP - Instituto De Salud Carlos Iii
item MICO, VICTOR - Imdea Institute
item COLMENAREJO, GONZALO - Imdea Institute
item GAFORIO, JOSE - Instituto De Salud Carlos Iii
item MATIA-MARTIN, PILAR - Health Research Institute Of The San Carlos Clinical Hospital
item ROS, EMILIO - Instituto De Salud Carlos Iii
item BUIL-COSIALES, PILAR - Instituto De Salud Carlos Iii
item VAZQUEZ-RUIZ, ZENAIDA - Instituto De Salud Carlos Iii
item SORLI, JOSE - Instituto De Salud Carlos Iii
item GRANIEL, INDIRA - Instituto De Salud Carlos Iii
item CUENCA-ROYO, AIDA - Hospital Del Mar Medical Research Institute
item GISBERT-SELLES, CRISTINA - Hospital Del Mar Medical Research Institute
item GALMES-PANADES, AINA - Instituto De Salud Carlos Iii
item ZULET, M. ANGELES - Instituto De Salud Carlos Iii
item GARCIA-RIOS, ANTONIO - Instituto De Salud Carlos Iii
item DIAZ-LOPEZ, ANDRES - Instituto De Salud Carlos Iii
item DE LA TORRE, RAFAEL - Instituto De Salud Carlos Iii
item GALILEA-ZABALZA, INIGO - Navarra Health
item ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Scientific Reports
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/27/2020
Publication Date: 2/26/2020
Citation: Daimiel, L., Martinez-Gonzalez, M.A., Corella, D., Salas-Salvado, J., Schroder, H., Vioque, J., Romaguera, D., Martinez, J.A., Warnberg, J., Lopez-Miranda, J., Estruch, R., Cano-Ibanez, N., Alonso-Gomez, A.M., Tur, J.A., Tinahones, F.J., Serra-Majem, L., Mico-Perez, R.M., Lapetra, J., Galdon, A., Pinto, X., Vidal, J., Mico, V., Colmenarejo, G., Gaforio, J.J., Matia-Martin, P., Ros, E., Buil-Cosiales, P., Vazquez-Ruiz, Z., Sorli, J.V., Graniel, I.P., Cuenca-Royo, A., Gisbert-Selles, C., Galmes-Panades, A.M., Zulet, M., Garcia-Rios, A., Diaz-Lopez, A., De La Torre, R., Galilea-Zabalza, I., Ordovas, J.M. 2020. Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial. Scientific Reports. 10(1):3472. https://doi.org/10.1038/s41598-020-59458-6.
DOI: https://doi.org/10.1038/s41598-020-59458-6

Interpretive Summary: Physical activity (PA) refers to any movement produced by skeletal muscle which uses energy. In contrast, physical fitness (PF) is a measurable state such as strength or endurance. PA may effectively maintain cognitive function and delay cognitive decline in the elderly. Still, physical fitness PF could be a better predictor of cognitive function. The purpose of the study was to investigate the association between PA and PF with cognitive function and quality of life using data from 6874 participants of the PREDIMED-Plus trial (64.9 +/- 4.9 years, 48.5% female). These analyses were conducted by investigators in Spain and at the HNRCA in Boston. PF, but not PA, is associated with better scores in the neurocognitive parameters evaluated. Nevertheless, both PF and PA levels were strongly associated with a better quality of life. In summary, PF, but not PA, is associated with a better cognitive function. Both PF and PA were associated with a higher quality of life.

Technical Abstract: Physical activity (PA) has been hypothesized to be effective to maintaining cognitive function and delay cognitive decline in the elderly, but physical fitness (PF) could be a better predictor of cognitive function. We aimed to study the association between PA and PF with cognitive function and quality of life using cross-sectional data from 6874 participants of the PREDIMED-Plus trial (64.9 +/- 4.9 years, 48.5% female). PF and PA were measured with a Chair Stand Test, the REGICOR and Rapid Assessment Physical Activity questionnaires. Cognitive function was measured with Mini-mental State Examination, Control Oral Word Association Test, Trail Making Test and Digit Span tests; whereas health-related quality of life was assessed with the SF36-HRQL test. Cognitive and quality of life scores were compared among PF quartiles and PA levels (low, moderate and high) with ANCOVA and with Chair Stand repetitions and energy expenditure from total PA with multivariable linear regression adjusted for confounding factors. PF associated with higher scores in phonemic and semantic verbal fluency tests and with lower TMT A time. However, PA was not associated with the neurocognitive parameters evaluated. Both PF and PA levels were strongly associated with a better quality of life. We concluded that PF, but not PA, is associated with a better cognitive function.