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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #396984
Research Project: Nutrient Metabolism and Musculoskeletal Health in Older Adults

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Intervention thresholds and diagnostic thresholds in the management of osteoporosis

Author
item KANIS, JOHN - University Of Sheffield
item MCCLOSKEY, EUGENE - University Of Sheffield
item HARVEY, NICHOLAS - University Of Southampton
item COOPER, CYRUS - University Of Southampton
item RIZZOLI, RENE - University Of Geneva
item DAWSON-HUGHES, BESS - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item MAGGI, STEFANIA - Consiglio Nazionale Delle Ricerche
item REGINSTER, JEAN-YVES - Who-Collaborating Centre For Epidemiology Of Musculoskeletal Conditions And Ageing

Submitted to: Aging Clinical Experimental Research
Publication Type: Other
Publication Acceptance Date: 7/29/2022
Publication Date: 11/7/2022
Citation: Kanis, J.A., Mccloskey, E.V., Harvey, N.C., Cooper, C., Rizzoli, R., Dawson-Hughes, B., Maggi, S., Reginster, J. 2022. Intervention thresholds and diagnostic thresholds in the management of osteoporosis. Aging Clinical Experimental Research. https://doi.org/10.1007/s40520-022-02216-7.
DOI: https://doi.org/10.1007/s40520-022-02216-7

Interpretive Summary:

Technical Abstract: The World Health Organization (WHO) bone mineral density (BMD)-based operational definition of osteoporosis has yielded a regulatory framework in the USA, the European Union, and elsewhere that has permitted development of important therapeutic interventions. The low rate of treatment in patients who have sustained a fragility fracture appears to underlie recent calls for a change in the diagnostic criteria for osteoporosis, but there is little evidence that this alone would improve management in such patients. In contrast, there is increasing evidence that the implementation of fracture liaison services through campaigns such as Capture the Fracture can improve access to better management and treatment of patients with osteoporosis. It is widely recognised that BMD alone for fracture risk assessment is less sensitive than risk assessment that incorporate risk indicators in addition to BMD. We recommend that the BMD-based definition of osteoporosis be retained whilst further clarity is brought to bear on the distinction between BMD-based diagnoses and intervention thresholds.