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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #396985
Research Project: Personalized Nutrition and Healthy Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Research gaps and opportunities in precision nutrition: an NIH workshop report

Author
item LEE, BRUCE - City University Of New York
item ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item PARKS, ELIZABETH - University Of Missouri
item ANDERSON, CHERYL - University Of California, San Diego
item BARABASI, ALBERT-LASZLO - Northeastern University
item CLINTON, STEVEN - The Ohio State University
item DE LA HAYE, KAYLA - University Of Southern California
item DUFFY, VALERIE - University Of Connecticut
item FRANKS, PAUL - Novo Nordisk, Inc
item GINEXI, ELIZABETH - National Institutes Of Health (NIH)
item HAMMOND, KRISTIAN - Northwestern University
item HANLON, ERIN - University Of Chicago
item HITTLE, MICHAEL - Stanford University
item HO, EMILY - Oregon State University
item HORN, ABIGAIL - University Of Southern California
item ISAACSON, RICHARD - Weill Medical College - Cornell
item MABRY, PATRICIA - Health Partners Research Foundation
item MALONE, SUSAN - New York University
item MARTIN, CORBY - Pennington Biomedical Research Center
item MATTEI, JOSIEMER - Harvard University
item MEYDANI, SIMIN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item NELSON, LORENE - Stanford University
item NEUHOUSER, MARIAN - Fred Hutchinson Cancer Research Center
item PARENT, BRENDAN - New York University
item PRONK, NICOLAAS - Health Partners Research Foundation
item ROCHE, HELEN - University College Dublin
item SAIRA, SUCHI - Johns Hopkins University
item SCHEER, FRANK - Harvard University
item SEGAL, ERAN - Weizmann Institite Of Science
item SEVICK, MARY ANN - New York University
item SPECTOR, TIM - King'S College
item VAN HORN, LINDA - Northwestern University
item VARADY, KRISTA - University Of Illinois
item SAROJA VORUGANTI, VENKATA - University Of North Carolina
item FERGUSON, MARIE - City University Of New York

Submitted to: The American Journal of Clinical Nutrition
Publication Type: Review Article
Publication Acceptance Date: 8/22/2022
Publication Date: 12/19/2022
Citation: Lee, B.Y., Ordovas, J.M., Parks, E.J., Anderson, C.A., Barabasi, A., Clinton, S.K., De La Haye, K., Duffy, V.B., Franks, P.W., Ginexi, E.M., Hammond, K.J., Hanlon, E.C., Hittle, M., Ho, E., Horn, A.L., Isaacson, R.S., Mabry, P.L., Malone, S., Martin, C.K., Mattei, J., Meydani, S.N., Nelson, L.M., Neuhouser, M., Parent, B.J., Pronk, N.P., Roche, H.M., Saira, S., Scheer, F.A., Segal, E., Sevick, M., Spector, T.D., Van Horn, L.B., Varady, K.A., Saroja Voruganti, V., Ferguson, M. 2022. Research gaps and opportunities in precision nutrition: an NIH workshop report. The American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqac237.
DOI: https://doi.org/10.1093/ajcn/nqac237

Interpretive Summary:

Technical Abstract: Precision nutrition is an emerging concept that aims to develop nutrition recommendations that are better tailored to different people's circumstances and biological characteristics. People's responses to dietary change and the resulting health outcomes from consuming different diets may vary significantly based on interactions among their genetic backgrounds, physiology, microbiome, underlying health status, behaviors, social influences, environmental exposures, and numerous other factors. On January 11-12, 2021, the National Institutes of Health (NIH) convened a workshop entitled "Precision Nutrition: Research Gaps and Opportunities" to bring together many experts to discuss the issues involved in better understanding and addressing precision nutrition. The Workshop proceeded in three parts: Part I covered many aspects of genetics and physiology that mediate the links between nutrient intake and health conditions such as cardiovascular disease, Alzheimer's disease, and cancer. Part II reviewed potential contributors to interindividual variability in dietary exposures and responses such as baseline nutritional status, circadian rhythm/sleep, environmental exposures, sensory properties of food, stress, inflammation, and the social determinants of health. Part III presented the need for systems approaches, with new methods and technologies that can facilitate the study and implementation of precision nutrition, and the training and workforce development needed to create a new generation of researchers. While precision nutrition offers tremendous promise to improve human health, it must proceed in a manner that does not introduce bias and inequity. The Workshop identified critical gaps and defined opportunities that are relevant to future investigations.