Location: Sustainable Biofuels and Co-products Research
Title: Genetic and process engineering for select glycolipid biosynthesis from plant/algal oils or their derivativesAuthor
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Submitted to: Book Chapter
Publication Type: Book / Chapter Publication Acceptance Date: 2/10/2023 Publication Date: N/A Citation: N/A Interpretive Summary: Technical Abstract: Microbial glycolipids, composed of fatty acid(s) linked to a carbohydrate moiety, are amphipathic surface-active molecules with numerous applications in food, textile, and cosmetic industries, as well as in medical and pharmaceutical industries. Glycolipids have important in vivo structural roles as components of the microbial cell surface or may be secreted extracellularly into the growth medium. Several microorganisms are emerging as suitable feedstocks for renewable production of these compounds. In addition, glycolipids can be produced in abundance using inexpensive substrates and low-value agricultural feedstocks, making their commercialization prospects more appealing. However, rational improvement to strain productivity of several glycolipid-producing microbes is limited by the scant knowledge on cellular metabolism, gene regulatory mechanisms, and the environmental factors influencing glycolipid accumulation. In this chapter, known genetic and metabolic regulations involved in the biosynthesis of low molecular weight glycolipids including rhamnolipid, sophorolipid, mannosylerythritol lipid, cellobiose lipid, and trehalose lipid produced by a variety of bacteria and yeasts are discussed. In addition, we will outline the knowledge available on the metabolic engineering strategies to enhance the quantity and quality of glycolipids produced from relevant microbial strains. |
