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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #402171
Research Project: Nutrition, Sarcopenia, Physical Function, and Skeletal Muscle Capacity During Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Resilience: biological basis and clinical significance - A perspective from the International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force

Author
item CESARI, MATTEO - UNIVERSITY OF MILAN
item AZZOLINO, DOMENICO - UNIVERSITY OF MILAN
item LEBRASSEUR, NATHAN - MAYO CLINIC
item WHITSON, HEATHER - DUKE UNIVERSITY
item ROOKS, DANIEL - NOVARTIS INSTITUTES
item SOURDET, SANDRINE - UNIVERSITY OF TOULOUSE
item ANGIONI, DAVID - UNIVERSITY OF TOULOUSE
item FIELDING, ROGER - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY
item VELLAS, BRUNO - UNIVERSITY OF TOULOUSE
item ROLLAND, YVES - UNIVERSITY OF TOULOUSE

Submitted to: The Journal of Frailty and Aging
Publication Type: Review Article
Publication Acceptance Date: 10/14/2022
Publication Date: 10/27/2022
Citation: Cesari, M., Azzolino, D., Lebrasseur, N.K., Whitson, H., Rooks, D., Sourdet, S., Angioni, D., Fielding, R., Vellas, B., Rolland, Y. 2022. Resilience: biological basis and clinical significance - A perspective from the International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force. The Journal of Frailty and Aging. https://doi.org/10.14283/jfa.2022.62.
DOI: https://doi.org/10.14283/jfa.2022.62

Interpretive Summary:

Technical Abstract: Resilience is a construct receiving growing attention from the scientific community in geriatrics and gerontology. Older adults show extremely heterogeneous (and often unpredictable) responses to stressors. Such heterogeneity can (at least partly) be explained by differences in resilience (i.e., the capacity of the organism to cope with stressors). The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force met in Boston (MA, USA) on April 20, 2022 to discuss the biological and clinical significance of resilience in older adults. The identification of persons with low resilience and the prompt intervention in this at-risk population may be critical to develop and implement preventive strategies against adverse events. Unfortunately, to date, it is still challenging to capture resilience, especially due to its dynamic nature encompassing biological, clinical, subjective, and socioeconomic factors. Opportunities to dynamically measure resilience were discussed during the ICFSR Task Force meeting, emphasizing potential biomarkers and areas of intervention. This article reports the results of the meeting and may serve to support future actions in the field.