Cellular senescence, a novel area of investigation for metastatic diseases

Authors: FAGGIOLI, FRANCESCA - Irccs Humanitas Research Hospital; VELARDE, MICHAEL - University Of The Philippines; WILEY, CHRISTOPHER - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Preprints
Publication Type: Review Article
Publication Acceptance Date: 11/30/2022
Publication Date: 11/30/2022
Citation: Faggioli, F., Velarde, M., Wiley, C. 2022. Cellular senescence, a novel area of investigation for metastatic diseases. Preprints. https://doi.org/10.20944/preprints202211.0564.v1.
DOI: https://doi.org/10.20944/preprints202211.0564.v1

Interpretive Summary:

Technical Abstract: Metastasis is a systemic condition and the major challenge among cancer types, as it can lead to multiorgan vulnerability. Recently, attention has been drawn to cellular senescence, a complex stress response condition, as a factor implicated in metastatic dissemination and outgrowth. Here, we examine the current knowledge of the features required for cells to invade and colonize secondary organs and how senescent cells can contribute to this process. First, we described the role of senescence in placentation, itself an invasive process which has been linked to higher rates of invasive cancers. Second, we describe how senescent cells can contribute to metastatic dissemination and colonization. Third, we discuss several metabolic adaptations by which senescent cells could promote cancer survival along the metastatic journey. In conclusion, we posit that targeting cellular senescence may have a potential therapeutic efficacy to limit metastasis formation.