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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #403560
Research Project: Personalized Nutrition and Healthy Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Personalized lifestyle intervention and functional evaluation health outcomes survey: presentation of the LIFEHOUSE study using N-of-One Tent-Umbrella-Bucket Design

Author
item LAMB, JOSEPH - Personalized Lifestyle Medicine Center
item SONE, MICHAEL - Personalized Lifestyle Medicine Center
item D'ADAMO, CHRISTOPHER - Institute For Functional Medicine Federal Way
item VOLKOV, ANDREY - Bennet Data Sciences
item METTI, DINA - Personalized Lifestyle Medicine Center
item ARONICA, LUCIA - Metagenics, Inc
item MINICH, DEANNA - Institute For Functional Medicine Federal Way
item LEARY, MICHELLE - Vida Integrated Health
item CLASS, MONIQUE - Institute For Functional Medicine Federal Way
item CARULLO, MALISA - Metagenics, Inc
item RYAN, JENNIFER - National University Of Natural Medicine
item LARSON, ILONA - Metagenics, Inc
item LUNDQUIST, ERIK - Personalized Lifestyle Medicine Center
item CONTRACTOR, NIKHAT - Metagenics, Inc
item ECK, BRENT - Metagenics, Inc
item ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item BLAND, JEFFREY - Personalized Lifestyle Medicine Center

Submitted to: Personalized Medicine
Publication Type: Review Article
Publication Acceptance Date: 1/11/2022
Publication Date: 1/15/2022
Citation: Lamb, J.J., Sone, M., D'Adamo, C.R., Volkov, A., Metti, D., Aronica, L., Minich, D., Leary, M., Class, M., Carullo, M., Ryan, J.J., Larson, I.A., Lundquist, E., Contractor, N., Eck, B., Ordovas, J.M., Bland, J.S. 2022. Personalized lifestyle intervention and functional evaluation health outcomes survey: presentation of the LIFEHOUSE study using N-of-One Tent-Umbrella-Bucket Design. Personalized Medicine. https://doi.org/10.3390/jpm12010115.
DOI: https://doi.org/10.3390/jpm12010115

Interpretive Summary:

Technical Abstract: The working definition of health is often the simple absence of diagnosed disease. This common standard is limiting given that changes in functional health status represent early warning signs of impending health declines. Longitudinal assessment of functional health status may foster prevention of disease occurrence and modify disease progression. The LIFEHOUSE (Lifestyle Intervention and Functional Evaluation-Health Outcomes SurvEy) longitudinal research project explores the impact of personalized lifestyle medicine approaches on functional health determinants. Utilizing an adaptive tent-umbrella-bucket design, the LIFEHOUSE study follows the functional health outcomes of adult participants recruited from a self-insured employee population. Participants were each allocated to the tent of an all-inclusive N-of-one case series. After assessing medical history, nutritional physical exam, baseline functional status (utilizing validated tools to measure metabolic, physical, cognitive, emotional and behavioral functional capacity), serum biomarkers, and genomic and microbiome markers, participants were assigned to applicable umbrellas and buckets. Personalized health programs were developed and implemented using systems biology formalism and functional medicine clinical approaches. The comprehensive database (currently 369 analyzable participants) will yield novel interdisciplinary big-health data and facilitate topological analyses focusing on the interactome among each participant's genomics, microbiome, diet, lifestyle and environment.