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Research Project: Intervention Strategies to Predict, Prevent, and Control Emerging Strains of Virulent Newcastle Disease Viruses

Location: Exotic & Emerging Avian Viral Diseases Research

Title: Complete genome sequence of seven virulent Newcastle disease virus isolates of sub-genotype XIII.1.1 from Tanzania

Author
item GORAICHUK, IRYNA - Orise Fellow
item MSOFFE, PETER - Sokoine University Of Agriculture
item CHIWANGA, GASPAR - Tanzania Veterinary Laboratory Agency
item DIMITROV, KIRIL - Texas A&M Veterinary Medical Diagnostic Laboratory
item Afonso, Claudio
item Suarez, David

Submitted to: Microbiology Resource Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/15/2023
Publication Date: 9/26/2023
Citation: Goraichuk, I., Msoffe, P.L., Chiwanga, G.H., Dimitrov, K., Afonso, C.L., Suarez, D.L. 2023. Complete genome sequence of seven virulent Newcastle disease virus isolates of sub-genotype XIII.1.1 from Tanzania. Microbiology Resource Announcements. e00405. https://doi.org/10.1128/MRA.00405-23.
DOI: https://doi.org/10.1128/MRA.00405-23

Interpretive Summary: Newcastle disease virus is a severe and often deadly disease of poultry and it widely distributed around the world. In Africa, Newcastle disease virus is one of the most severe diseases of backyard poultry, which still remains an important food source in many countries. Although vaccination can be protective, availability and cost of vaccination is an impediment for wider use. As part of study of viruses in live bird markets in Tanzania, multiple Newcastle disease viruses were isolated from chickens. Seven of these isolates were fully sequenced and those viruses provide the first full length sequences from this region. Having a clear understanding of what genotype of virus is circulating in a country allows improved control measures.

Technical Abstract: We report the complete genome sequences of seven virulent Newcastle disease viruses (NDVs) that were isolated from chickens from live bird markets in the Arusha, Iringa, Mbeya, and Tanga regions of Tanzania in 2012. Phylogenetic analysis revealed that all isolates belong to sub-genotype XIII.1.1.