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ARS Home » Plains Area » Clay Center, Nebraska » U.S. Meat Animal Research Center » Nutrition, Growth and Physiology » Research » Publications at this Location » Publication #405322
Research Project: Optimizing Nutrient Management and Efficiency of Beef Cattle and Swine

Location: Nutrition, Growth and Physiology

Title: Role of the placenta in developmental programming: Observations from models using large animals

Author
item REYNOLDS, L - North Dakota State University
item DAHLEN, C - North Dakota State University
item WARD, A - North Dakota State University
item Crouse, Matthew
item BOROWICZ, P - North Dakota State University
item DAVILA-RUIZ, B - North Dakota State University
item KANJANARUCH, C - North Dakota State University
item BOCHANTIN, K - North Dakota State University
item MCLEAN, K - University Of Tennessee
item MCCARTHY, K - University Of Nebraska
item MENEZES, A - North Dakota State University
item DINIZ, W - Auburn University
item Cushman, Robert - Bob
item CATON, J - North Dakota State University

Submitted to: Animal Reproduction Science
Publication Type: Review Article
Publication Acceptance Date: 8/23/2023
Publication Date: 10/1/2023
Citation: Reynolds, L.P., Dahlen, C.R., Ward, A.K., Crouse, M.S., Borowicz, P.P., Davila-Ruiz, B.J., Kanjanaruch, C., Bochantin, K.A., McLean, K.J., McCarthy, K.L., Menezes, A.C.B., Diniz, W.J.S., Cushman, R.A., Caton, J.S. 2023. Role of the placenta in developmental programming: Observations from models using large animals. Animal Reproduction Science. 257. Article 107322. https://doi.org/10.1016/j.anireprosci.2023.107322.
DOI: https://doi.org/10.1016/j.anireprosci.2023.107322

Interpretive Summary:

Technical Abstract: Developmental programming, which proposes that “insults” or “stressors” during intrauterine or postnatal development can have not only immediate but also long-term consequences for healthy and productivity, has emerged as a major biological principle, and based on studies in many animal species also seems to be a universal phenomenon. In eutherians, the placenta appears to be programmed during its development, which has consequences for fetal growth and development throughout pregnancy, and likewise has long-term consequences for postnatal development, leading to programming of organ function of the offspring even into adulthood. This review summarizes our current understanding of the placenta’s role in developmental programming, the mechanisms involved, and the challenges remaining.