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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #405780
Research Project: Energy Met.: Novel Approaches to Facilitating Successful Energy Regulation in Aging--Obesity & Met.: Role of Adipocyte Metabolism in the Development of Obesity and Associated Metabolic Complications

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: No effect of calorie restriction or dietary patterns on spatial working memory during a two-year intervention: a secondary analysis of the CALERIE trial

Author
item SILVER, RACHEL - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY
item DAS, SAI KRUPA - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY
item KRAMER, ARTHUR - NORTHEASTERN UNIVERSITY
item CHUI, KENNETH - TUFTS UNIVERSITY
item ROBERTS, SUSAN - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY

Submitted to: Journal of Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/12/2023
Publication Date: 3/1/2023
Citation: Silver, R., Das, S., Kramer, A.F., Chui, K.K., Roberts, S. 2023. No effect of calorie restriction or dietary patterns on spatial working memory during a two-year intervention: a secondary analysis of the CALERIE trial. Journal of Nutrition. https://doi.org/10.1016/j.tjnut.2023.01.019.
DOI: https://doi.org/10.1016/j.tjnut.2023.01.019

Interpretive Summary: Widespread changes in the brain occur as adults age and are accompanied by declines in cognitive functioning. Evidence suggests that nutritional strategies, such as consuming a healthy diet or reducing the number of calories consumed each day, might help to slow cognitive decline. We compared the effect of a healthy diet on cognition for among healthy participants randomly assigned to a calorie restriction intervention (143 participants) or to a control group (76 participants). Changes in dietary intake and cognitive functioning were measured during the two-year intervention. Participants in both groups tended to improve their cognitive function over time, suggesting that neither calorie restriction nor a healthy diet played a role in these improvements. Further research is needed to understand the role of diet on cognitive health in diverse populations.

Technical Abstract: Objectives: The effect of calorie restriction (CR) on cognitive function is controversial, and the effects of consuming a healthy dietary pattern during CR have not been investigated. Furthermore, there is no consensus on what dietary pattern may be the most beneficial for cognition. We analyzed the combined effects of CR and self-selected diet on measures of spatial working memory (SWM) in healthy adults without obesity. Methods: Publicly available data from the CALERIE trial were analyzed. Participants were randomized to a 2-year CR intervention (n=143) or an ad libitum Control (n=76). Food records were collected at baseline, 12, and 24 months. The Dietary Inflammatory Index (DII) and the Healthy Eating Index (HEI-2015) were calculated to quantify different measures of dietary healthfulness, where a lower DII and a higher HEI-2015 indicate a healthier score. Cognitive function was assessed by the CANTAB battery, with fewer errors indicating better SWM. Changes in each index during the intervention were assessed by linear mixed models. Longitudinal associations between the indices and SWM were assessed by multivariable negative binomial models. Results: On average, participants were 38.1+/-7.2 years old with a BMI of 25.1+/-1.7 kg/m2. The average DII and HEI-2015 scores at baseline were -0.47 (range: -4.02, 3.19) and 59.1 (24.1, 91.0) and did not significantly differ between groups. Improvements in DII and HEI-2015 were significantly different between CR and Control over time (P interaction < 0.0001), with greater improvements in CR. In longitudinal analyses, there was no significant effect of improving the healthfulness of the DII or HEI-2015 on SWM. In addition, though there were significant within-group improvements in SWM at 12 months, there was no significant difference between the changes observed in CR (adjusted mean difference: 10.0; 95% CI: 2.2, 45.7) and Control (13.1; 95% CI: 2.9, 59.3; P = 0.93). Comparable results were observed at 24 months. Conclusions: Neither CR nor the healthfulness of the diet were associated with SWM, suggesting that that the potential for CR and dietary patterns to have beneficial effects on working memory may be limited in healthy populations. Further research is required to understand the role of diet in cognitive function in at-risk populations.