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ARS Home » Southeast Area » Auburn, Alabama » Soil Dynamics Research » Research » Publications at this Location » Publication #406045
Research Project: Conservation Systems to Improve Production Efficiency, Reduce Risk, and Promote Sustainability

Location: Soil Dynamics Research

Title: Maternal mineral nutrition regulates fetal genomic programming in cattle: a review

Author
item ANAS, M - North Dakota State University
item DINIZ, W - Auburn University
item MENEZES, A - South Dakota State University
item REYNOLDS, L - Auburn University
item CATON, J - North Dakota State University
item DAHLEN, C - North Dakota State University
item WARD, A - University Of Saskatchewan

Submitted to: Metabolites
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 4/24/2023
Publication Date: 4/26/2023
Citation: Anas, M., Diniz, W.J., Menezes, A.C., Reynolds, L.P., Caton, J.S., Dahlen, C.R., Ward, A.K. 2023. Maternal mineral nutrition regulates fetal genomic programming in cattle: a review. Metabolites. 13(5):593. https://doi.org/10.3390/metabo13050593.
DOI: https://doi.org/10.3390/metabo13050593

Interpretive Summary: Maternal mineral nutrition during the critical phases of fetal development may leave lifetime impacts on the productivity of an individual. Most research within the developmental origins of the health and disease (DOHaD) field is focused on the role of macronutrients in the genome function and programming of the developing fetus. On the other hand, there is a paucity of knowledge about the role of micronutrients and, specifically, minerals in regulating the epigenome of livestock species, especially cattle. This review addressed the effects of the maternal dietary mineral supply on the fetal developmental programming from the embryonic to the postnatal phases in cattle.

Technical Abstract: Maternal mineral nutrition during the critical phases of fetal development may leave lifetime impacts on the productivity of an individual. Most research within the developmental origins of the health and disease (DOHaD) field is focused on the role of macronutrients in the genome function and programming of the developing fetus. On the other hand, there is a paucity of knowledge about the role of micronutrients and, specifically, minerals in regulating the epigenome of livestock species, especially cattle. Therefore, this review will address the effects of the maternal dietary mineral supply on the fetal developmental programming from the embryonic to the postnatal phases in cattle. To this end, we will draw a parallel between findings from our cattle model research with data from model animals, cell lines, and other livestock species. The coordinated role and function of different mineral elements in feto-maternal genomic regulation underlies the establishment of pregnancy and organogenesis and, ultimately, affects the development and functioning of metabolically important tissues, such as the fetal liver, skeletal muscle, and, importantly, the placenta. Through this review, we will delineate the key regulatory pathways involved in fetal programming based on the dietary maternal mineral supply and its crosstalk with epigenomic regulation in cattle.