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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #406055
Research Project: Exploiting Nutrition and Protein Quality Controls to Delay Age-related Macular Degeneration and Cataracts

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Inside out: relations between the microbiome, nutrition, and eye health

Author
item GRANT, MARIA - University Of Alabama At Birmingham
item BERNSTEIN, PAUL - University Of Utah
item BOESZE-BATTAGLIA, KATHLEEN - University Of Pennsylvania
item CHEW, EMILY - National Eye Institute
item CURCIO, CHRISTINE - University Of Alabama At Birmingham
item KENNEY, M - University Of California Irvine
item KLAVER, CAROLINE - Erasmus Medical Center
item PHILP, NANCY - Thomas Jefferson University
item ROWAN, SHELDON - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item SPARROW, JANET - Columbia University - New York
item SPAIDE, RICHARD - Macula Consultants Of New York
item TAYLOR, ALLEN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Experimental Eye Research
Publication Type: Review Article
Publication Acceptance Date: 8/8/2022
Publication Date: 11/1/2022
Citation: Grant, M.B., Bernstein, P.S., Boesze-Battaglia, K., Chew, E.0., Curcio, C.A., Kenney, M.C., Klaver, C., Philp, N., Rowan, S., Sparrow, J., Spaide, R.F., Taylor, A. 2022. Inside out: relations between the microbiome, nutrition, and eye health. Experimental Eye Research. https://doi.org/10.1016/j.exer.2022.109216.
DOI: https://doi.org/10.1016/j.exer.2022.109216

Interpretive Summary:

Technical Abstract: Age-related macular degeneration (AMD) is a complex disease with increasing numbers of individuals being afflicted and treatment modalities limited. There are strong interactions between diet, age, the metabolome, and gut microbiota, and all of these have roles in the pathogenesis of AMD. Communication axes exist between the gut microbiota and the eye, therefore, knowing how the microbiota influences the host metabolism during aging could guide a better understanding of AMD pathogenesis. While considerable experimental evidence exists for a diet-gut-eye axis from murine models of human ocular diseases, human diet-microbiome-metabolome studies are needed to elucidate changes in the gut microbiome at the taxonomic and functional levels that are functionally related to ocular pathology. Such studies will reveal new ways to diminish risk for progression of- or incidence of- AMD. Current data suggest that consuming diets rich in dark fish, fruits, vegetables, and low in glycemic index are most retina-healthful during aging.