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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #408753
Research Project: Nutrition, Sarcopenia, Physical Function, and Skeletal Muscle Capacity During Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Outcomes for regulatory approval in geriatrics: embracing loss of mobility and mobility disability as clinically meaningful therapeutic indications

Author
item FIELDING, ROGER - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item LEBRASSEUR, NATHAN - Mayo Clinic

Submitted to: Journal of Nutrition Health and Aging
Publication Type: Other
Publication Acceptance Date: 6/22/2023
Publication Date: 7/4/2023
Citation: Fielding, R., Lebrasseur, N.K. 2023. Outcomes for regulatory approval in geriatrics: embracing loss of mobility and mobility disability as clinically meaningful therapeutic indications. Journal of Nutrition Health and Aging. https://doi.org/10.1007/s12603-023-1944-7.
DOI: https://doi.org/10.1007/s12603-023-1944-7

Interpretive Summary:

Technical Abstract: The significant interest in aging, aging-related conditions, and geriatric syndromes has generated new ideas and approaches for optimizing late-life health. The successful advancement of novel therapies will depend on an evidence- and consensus-based roadmap to regulatory approval. Reduced mobility and mobility disability are clinically important geriatric conditions for which there are no approved pharmacological interventions. These indications can be easily and routinely assessed in randomized trials through several valid and reliable measures that demonstrate responsiveness to change that are clinically meaningful.