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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #408810
Research Project: Nutrition, Sarcopenia, Physical Function, and Skeletal Muscle Capacity During Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Biomarkers of cellular senescence and risk of death in humans

Author
item ST. SAUVER, JENNIFER - Mayo Clinic
item WESTON, SUSAN - Mayo Clinic
item ATKINSON, ELIZABETH - Mayo Clinic
item MC GREE, MICHAELA - Mayo Clinic
item MIELKE, MICHELLE - Wake Forest University
item WHITE, THOMAS - Mayo Clinic
item HEEREN, AMANDA - Mayo Clinic
item OLSON, JANET - Mayo Clinic
item ROCCA, WALTER - Mayo Clinic
item PALMER, ALLYSON - Mayo Clinic
item CUMMINGS, STEVEN - University Of California San Francisco (UCSF)
item FIELDING, ROGER - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item BIELINSKI, SUZETTE - Mayo Clinic
item LEBRASSEUR, NATHAN - Mayo Clinic

Submitted to: Aging Cell
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/19/2023
Publication Date: 10/6/2023
Citation: St. Sauver, J.L., Weston, S.A., Atkinson, E.J., Mc Gree, M.M., Mielke, M.M., White, T.A., Heeren, A.A., Olson, J.E., Rocca, W.A., Palmer, A.K., Cummings, S.R., Fielding, R., Bielinski, S.J., Lebrasseur, N.K. 2023. Biomarkers of cellular senescence and risk of death in humans. Aging Cell. https://doi.org/10.1111/acel.14006.
DOI: https://doi.org/10.1111/acel.14006

Interpretive Summary: Cellular senescence is a process related to the aging of many cells in our bodies and may be associated with mortality in older adults. Associations between markers of cellular senescence in the blood and death were examined in 1,923 healthy older adults. Five senescence markers were associated with an increased risk of death after adjusting for age, sex, race, and the presence of one chronic condition. These findings lend further support that biomarkers of cellular senescence are informative predictors of clinically important health outcomes in older adults, including death.

Technical Abstract: A robust and heterogenous secretory phenotype is a core feature of most senescent cells. In addition to mediators of age-related pathology, components of the senescence associated secretory phenotype (SASP) have been studied as biomarkers of senescent cell burden and, in turn, biological age. Therefore, we hypothesized that circulating concentrations of candidate senescence biomarkers, including chemokines, cytokines, matrix remodeling proteins, and growth factors, could predict mortality in older adults. We assessed associations between plasma levels of 28 SASP proteins and risk of mortality over a median follow-up of 6.3 years in 1,923 patients 65 years of age or older with zero or one chronic condition at baseline. Overall, 5 senescence biomarkers-GDF15, RAGE, VEGF, PARC, and MMP2-were associated with an increased risk of death after adjusting for age, sex, race, and the presence of one chronic condition (all P values<0.005). The combination of biomarkers and clinical and demographic covariates exhibited a significantly higher c-statistic for risk of death (0.79, 95% confidence interval (CI): 0.75-0.82) than the covariates alone (0.70, CI: 0.67-0.74) (p < 0.001). Collectively, these findings lend further support to biomarkers of cellular senescence as informative predictors of clinically important health outcomes in older adults, including death.