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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Environmental Microbial & Food Safety Laboratory » Research » Publications at this Location » Publication #410627
Research Project: Detection and Characterization of Zoonotic and Emerging Parasites Affecting Food Safety and Public Health

Location: Environmental Microbial & Food Safety Laboratory

Title: The first Cyclospora cayetanensis lineage A genome from an isolate from Mexico

Author
item Santin-Duran, Monica
item Molokin, Aleksey
item OROZCO-MOSQUEDA, GUADALUPE - Collaborator
item ALMERIA, SONIA - Us Food & Drug Administration (FDA)
item Maloney, Jenny

Submitted to: Veterinary Parasitology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/26/2024
Publication Date: 3/5/2024
Citation: Santin, M., Molokin, A., Orozco-Mosqueda, G.E., Almeria, S., Maloney, J.G. 2024. The first Cyclospora cayetanensis lineage A genome from an isolate from Mexico. Veterinary Parasitology. 25: Article e246. https://doi.org/10.1186/s12864-024-10163-y.
DOI: https://doi.org/10.1186/s12864-024-10163-y

Interpretive Summary: Cyclospora cayetanensis is a protozoan parasite that causes intestinal illness in humans worldwide. However, the genomes that are available for C. cayetanensis do not cover the many different geographic areas where this parasite is found. To fill this data gap, we have sequenced a C. cayetanensis genome from a child living in Mexico. This genome represents the first lineage A genome from Mexico and expands our knowledge on the genetic diversity C. cayetanensis. This research provides important information that can be used to improve the detection and control of this common foodborne pathogen.

Technical Abstract: Cyclospora cayetanensis is a protozoan parasite that causes intestinal illness in humans worldwide. Despite its global distribution, most genomic data for C. cayetanensis has been obtained from isolates collected in the United States, leaving genetic variability among globally distributed isolates underexplored. In the present study, the genome of an isolate of C. cayetanensis obtained from a child with diarrhea living in Mexico was sequenced and assembled. Evaluation of the assembly using a lineage typing system recently developed by the Centers for Disease Control and Prevention revealed that this isolate is lineage A. Given that the only other whole genome assembly available from Mexico was classified as lineage B, the data presented here represent an important step in expanding our knowledge of the diversity of C. cayetanensis isolates from Mexico at the genomic level.