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Research Project: Impact of Maternal Influence and Early Dietary Factors on Child Growth, Development, and Metabolic Health

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Title: The Role of Early-Life Gut Mycobiome on Child Health

Author
item RODRIGUEZ, KAYLEIGH - University Arkansas For Medical Sciences (UAMS)
item Gurung, Manoj
item Talatala, Rachelanne
item Rearick, Jolene
item Ruebel, Meghan
item STEPHENS, KIMBERLY - University Arkansas For Medical Sciences (UAMS)
item Yeruva, Laxmi

Submitted to: Advances in Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/31/2024
Publication Date: 2/3/2024
Citation: Rodriguez, K.A., Gurung, M., Talatala, R., Rearick, J.R., Ruebel, M., Stephens, K.E., Yeruva, V. 2024. The Role of Early-Life Gut Mycobiome on Child Health. Advances in Nutrition. 15(3):100185. https://doi.org/10.1016/j.advnut.2024.100185.
DOI: https://doi.org/10.1016/j.advnut.2024.100185

Interpretive Summary: Gut microbiota involved in host physiological functions has been studied for the past 15 years. However, human gut is composed of bacteria (microbiota or microbiome), fungi (mycobiome), viruses, and archaea, and most of the research is primarily focused on the bacterial component of this ecosystem. Besides bacteria, fungi have been shown to play a role in host health. However, studies on mycobiota composition during infancy and the factors that might shape infant gut mycobiota and implications to child health and development are limited. In this review, we discuss the factors likely shaping gut mycobiota, interkingdom interaction and association to child health outcomes and highlight the gap in knowledge.

Technical Abstract: Gut microbiota involved in host physiological functions has been studied for the past 15 years. However, human gut is composed of bacteria (microbiota or microbiome), fungi (mycobiome), viruses, and archaea, and most of the research is primarily focused on the bacterial component of this ecosystem. Besides bacteria, fungi have been shown to play a role in host health. However, studies on mycobiota composition during infancy and the factors that might shape infant gut mycobiota and implications to child health and development are limited. In this review, we discuss the factors likely shaping gut mycobiota, interkingdom interaction and association to child health outcomes and highlight the gap in knowledge.