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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #411008
Research Project: Personalized Nutrition and Healthy Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: The epigenetics of early cardiovascular and metabolic diseases development: from mechanisms to precision medicine

Author
item BACCARELLI, ANDREA - Columbia University - New York
item ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Circulation Research
Publication Type: Review Article
Publication Acceptance Date: 5/10/2023
Publication Date: 6/9/2023
Citation: Baccarelli, A., Ordovas, J.M. 2023. The epigenetics of early cardiovascular and metabolic diseases development: from mechanisms to precision medicine. Circulation Research. 132,1648-1662. https://doi.org/10.1161/CIRCRESAHA.123.322135.
DOI: https://doi.org/10.1161/CIRCRESAHA.123.322135

Interpretive Summary:

Technical Abstract: Epigenetics has transformed our understanding of the molecular basis of complex diseases, including cardiovascular and metabolic disorders. This review offers a comprehensive overview of the current state of knowledge on epigenetic processes implicated in cardiovascular and metabolic diseases, highlighting the potential of DNA methylation as a precision medicine biomarker and examining the impact of social determinants of health, gut bacterial epigenomics, non-coding RNA, and epitranscriptomics on disease development and progression. We discuss challenges and barriers to advancing cardiometabolic epigenetics research, along with the opportunities for novel preventive strategies, targeted therapies, and personalized medicine approaches that may arise from a better understanding of epigenetic processes. Emerging technologies, such as single-cell sequencing and epigenetic editing, hold the potential to further enhance our ability to dissect the complex interplay between genetic, environmental, and lifestyle factors. To translate research findings into clinical practice, interdisciplinary collaborations, technical and ethical considerations, and accessibility of resources and knowledge are crucial. Ultimately, the field of epigenetics has the potential to revolutionize the way we approach cardiovascular and metabolic diseases, paving the way for precision medicine and personalized healthcare, and improving the lives of millions of individuals worldwide affected by these conditions