Complete genome sequence of an ovine ancestral strain of Mycobacterium avium subspecies paratuberculosis 6756

Authors: BIET, FRANCK - Universite De Tours; CONDE, CYRIL - Universite De Tours; COCHARD, THIERRY - Universite De Tours; MCINTOSH, FIONA - McGill University - Canada; BEHR, MARCEL - McGill University - Canada; Bannantine, John

Submitted to: Microbiology Resource Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/24/2024
Publication Date: 3/5/2024
Citation: Biet, F., Conde, C., Cochard, T., McIntosh, F.A., Behr, M.A., Bannantine, J.P. 2024. Complete genome sequence of an ovine ancestral strain of Mycobacterium avium subspecies paratuberculosis 6756. Microbiology Resource Announcements. 13(4). https://doi.org/10.1128/mra.01207-23.
DOI: https://doi.org/10.1128/mra.01207-23

Interpretive Summary: We report the complete genome sequence of a rare type I strain of Mycobacterium avium subspecies paratuberculosis (Map). Only one other type I strain genome is available and we needed this information for our future studies examining the lipid differences between type I, II, and III strains of Map. With two of these genomes now available, annotated and searchable, we can make important conclusions about other ongoing studies. This information is of interest mostly to scientists working in the field.

Technical Abstract: The complete genome sequence of the most ancestral type I strain of Mycobacterium avium subspecies paratuberculosis was determined. The genome was sequenced using the PacBio technology, yielding a genome size of 4,830,294 nucleotides with no plasmid for this strain designated 6756 which was isolated from a sheep.