Location: Food Animal Metabolism Research
Title: Fate of [14C]-polystyrene microplastics after oral administration in lactating sheepAuthor
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Submitted to: American Chemical Society Abstracts
Publication Type: Abstract Only Publication Acceptance Date: 5/21/2024 Publication Date: 5/21/2024 Citation: Shelver, W.L., Mcgarvey, A.M., Billey, L.O. 2024. Fate of [14C]-polystyrene microplastics after oral administration in lactating sheep. American Chemical Society Abstracts. PAPER ID: 4091310. Interpretive Summary: Technical Abstract: Microplastics have become a ubiquitous contaminant, but their fate in food animals is largely unknown. In this study, [14C]-polystyrene microplastic (PS-MP) was orally dosed in lactating sheep to evaluate its disposition. Elimination of the [14C]-PS-MP was predominately through feces and the radio-activities peaked at 24-hour’s post-dosing but continued to be present in excreta throughout the entire 72-hour study period. Only small fractions (= 1%) of the dosed [14C]-PS-MP were present in blood, milk, and urine. Pharmacokinetic analysis using non-compartment modeling, showed rapid absorption (T1/2 0.4 to 3 hours) and slow elimination (T1/2 30 to 40 hours) in plasma. Milk and urine concentrations had similar elimination patterns with radiocarbon activities peaking 24-hour post-dosing and continuing to be eliminated throughout the 72-hour period although the concentration at 72 hours was low. No radioactivity was measured in tissues at 72-hour withdrawal. |
