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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #414711
Research Project: Nutrient Metabolism and Musculoskeletal Health in Older Adults

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Optimization of vitamin D status in global populations

Author
item HARVEY, NICOLAS - University Of Southampton
item WARD, KATE - University Of Southampton
item AGNUSDEI, DONATO - University Of Siena
item BINKLEY, NEIL - University Of Wisconsin
item BIVER, EMMANUEL - University Of Geneva
item CAMPUSANO, CLAUDIA - Universidad De Los Andes
item CAVALIER, ETIENNE - University Of Liege
item CLARK, PATRICIA - The National Autonomous University Of Mexico
item DIAZ-CURIEL, MANUEL - Iis-Fundacion Jimenez Diaz
item EL-HAJJ FULEIHAN, GHADA - American University Of Beirut
item KHASHAYER, PATRICIA - University Of Minnesota
item LANE, NANCY - University Of California, Davis
item MESSINA, OSVALDO - World Health Organization (WHO)
item MITHAL, AMBRISH - Max Healthcare
item RIZZOLI, RENE - Geneva University Hospital
item SEMPOS, CHRIS - Vitamin D Standardization Program (VDSP) Llc
item DAWSON-HUGHES, BESS - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Osteoporosis International
Publication Type: Review Article
Publication Acceptance Date: 5/10/2024
Publication Date: 6/5/2024
Citation: Harvey, N.C., Ward, K.A., Agnusdei, D., Binkley, N., Biver, E., Campusano, C., Cavalier, E., Clark, P., Diaz-Curiel, M., El-Hajj Fuleihan, G., Khashayer, P., Lane, N.E., Messina, O.D., Mithal, A., Rizzoli, R., Sempos, C., Dawson-Hughes, B. 2024. Optimization of vitamin D status in global populations. Osteoporosis International. https://doi.org/10.1007/s00198-024-07127-z.
DOI: https://doi.org/10.1007/s00198-024-07127-z

Interpretive Summary:

Technical Abstract: Vitamin D is important for musculoskeletal health. Concentrations of 25-hydroxyvitamin D, the most commonly measured metabolite, vary markedly around the world and are influenced by many factors including sun exposure, skin pigmentation, covering, season and supplement use. Whilst overt vitamin D deficiency with biochemical consequences presents an increased risk of severe sequelae such as rickets, osteomalacia or cardiomyopathy and usually warrants prompt replacement treatment, the role of vitamin D supplementation in the population presents a different set of considerations. Here the issue is to keep, on average, the population at a level whereby the risk of adverse health outcomes in the population is minimized. This position paper, which builds on recently published work from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, addresses key considerations regarding vitamin D assessment and intervention from the population perspective.