Location: Plant Gene Expression Center
Title: Clathrin light chains negatively regulate plant immunity by highjacking the autophagy pathwayAuthor
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LAN, HU-JIAO - Zhejiang Normal University |
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RAN, JIE - Zhejiang Normal University |
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WANG, WEN-XU - Zhejiang Normal University |
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ZHANG, LEI - Zhejiang Normal University |
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WU, NI-NI - Zhejiang Normal University |
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ZHAO, YA-TING - Zhejiang Normal University |
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HUANG, MIN-JUN - Zhejiang Normal University |
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NI, MIN - Zhejiang Normal University |
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LIU, FEN - Chinese Academy Of Agricultural Sciences |
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CHENG, NINGHUI - Baylor College Of Medicine |
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NAKATA, PAUL - Baylor College Of Medicine |
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PAN, JIANWEI - Lanzhou University |
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WHITHAM, STEVEN - Iowa State University |
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Baker, Barbara |
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LIU, JIAN-ZHONG - Zhejiang Normal University |
Submitted to: Plant Communications
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 4/28/2024 Publication Date: 7/8/2024 Citation: Lan, H., Ran, J., Wang, W., Zhang, L., Wu, N., Zhao, Y., Huang, M., Ni, M., Liu, F., Cheng, N., Nakata, P.A., Pan, J., Whitham, S.A., Baker, B.J., Liu, J. 2024. Clathrin light chains negatively regulate plant immunity by highjacking the autophagy pathway. Plant Communications. 5. Article 100937. https://doi.org/10.1016/j.xplc.2024.100937. DOI: https://doi.org/10.1016/j.xplc.2024.100937 Interpretive Summary: Clathrin plays a critical role in clathrin-mediated endocytosis (CME) in plants, and it is also required for autophagy in mammals. However, the functional interconnection of clathrin with autophagy, and its role in plant defense have not been established in plants. Here, we demonstrated that loss of function of CLATHRIN LIGHT CHAIN (CLC) subunit 2 and 3 resulted in Salicylic acid (SA)- and Reactive oxygen species (ROS)-dependent autoimmune responses in Arabidopsis, which are hallmarks of the AUTOPHAGY-RELATED GENE (ATG) mutants and thus linking clathrin-mediated endocytosis (CME) to autophagy and plant defense. Technical Abstract: Clathrin plays a critical role in clathrin-mediated endocytosis (CME) in plants, and it is also required for autophagy in mammals. However, the functional interconnection of clathrin with autophagy, and its role in plant defense have not been established in plants. Here, we demonstrated that loss of function of CLATHRIN LIGHT CHAIN (CLC) subunit 2 and 3 resulted in Salicylic acid (SA)- and Reactive oxygen species (ROS)-dependent autoimmune responses in Arabidopsis, which are hallmarks of the AUTOPHAGY-RELATED GENE (ATG) mutants and thus linking clathrin-mediated endocytosis (CME) to autophagy and plant defense. |