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Research Project: Impact of Maternal Influence and Early Dietary Factors on Child Growth, Development, and Metabolic Health

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Title: Interaction of glycolytic end-products with myoglobin and its effect on oxygen kinetics

Author
item ADEPU, KIRIN KUMAR - Arkansas Children'S Nutrition Research Center (ACNC)
item BHANDARI, DIPENDRA - Arkansas Children'S Nutrition Research Center (ACNC)
item CHINTAPALLI, SREE - Arkansas Children'S Nutrition Research Center (ACNC)

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 9/18/2023
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Aside from functioning as an oxygen (O2) carrier/storage protein and nitric oxide (NO) scavenger, myoglobin (Mb) might also be involved in lipid trafficking and metabolite binding. Our recent research has revealed that glycolytic end-products (pyruvate, PYR and lactate, LAC) interact with both oxygenated (oxy-) and deoxygenated (deoxy-) myoglobin, exhibiting distinct pH-dependent binding characteristics and efficiently releasing O2 from oxy-Mb. These findings substantiate the notion that glycolytic end-products may have a unique role in tissues rich in Mb, potentially acting as innovative regulators of O2 management and availability. Furthermore, they could potentially influence other activities associated with the toggling of oxyand deoxy-Mb in conditions of rest compared to exercise or increased metabolic activity.